A structured, continuously updated evidence base for chronic illness — combining peer-reviewed research with real-world patient experience across 77 conditions. Built for patients and clinicians alike, with full transparency on where every data point comes from.
What You Need to Know About Sacroiliac Dysfunction.
Low back pain is the leading cause of disability worldwide, and sacroiliac dysfunction is estimated to occur in 15%-30% of those with nonspecific low back pain. Nurses are in the unique position to support and provide education to patients who may be experiencing sacroiliac dysfunction or possibly a…
The purpose of this study is to investigate the association between cannabis usage and thyroid eye disease (TED) in patients with autoimmune hyperthyroidism. While the association between cigarette smoking and TED is well established, the effect of cannabis on TED is unclear. This cohort study exami…
Recognition of Cutaneous Symptoms of Common Tick-Borne Illness in the Emergency Department.
Tick-borne diseases occur throughout the United States, with a disease burden that ranges from mild to severe. As temperatures rise with climate change, the active season for ticks increases, and more tick-borne illness is seen (Centers for Disease Control and Prevention, 2022a). Many patients prese…
Quantitative Analysis of Placebo Response Models to Optimize Clinical Trials in Premenstrual Disorders: A Model-Based Meta-analysis.
This study quantitatively analyze the evaluation indicators used in premenstrual disorder clinical trials, establishes a placebo response model, observes its influencing factors, and provides a basis for the design of future clinical trials. A comprehensive search was conducted in PubMed, EMBASE, Co…
Early Postoperative Magnetic Resonance Imaging Findings Related to Electrocauterization for Cerebellar Reduction During Chiari Decompression Surgery.
Cerebellar tonsillar reduction or resection can be performed as part of the surgical management of Chiari type 1 malformation when it is accompanied by symptomatic brainstem compression or syringomyelia. The purpose of this study is to characterize the early postoperative magnetic resonance imaging…
Cytotoxic Lesion of the Corpus Callosum After Hospital-Administered Intravenous Fentanyl for Trigeminal Neuralgia: A Case Report and Focused Review.
Fentanyl-associated neurotoxicity is increasingly recognized across illicit, inhalational, transdermal, pediatric, and delayed posthypoxic exposures, but isolated splenial CLOCC after hospital-administered intravenous fentanyl has not been well characterized. This is a single-patient case report wit…
Examining Cost Differences in Malignant Brain and Central Nervous System Tumor Treatment Across US Military Health System Care Settings.
The objectives of this study were to determine whether the cost of care for malignant brain and other central nervous system tumors (MBT) in the US Military Health System differs between the Department of War-operated direct care (DC) network and the affiliated civilian-operated private sector care…
Complications and Management of Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders: A Literature Review.
Ehlers-Danlos syndrome (EDS) is a group of inherited disorders affecting collagen and extracellular matrix proteins, which can cause skin hyperelasticity, joint hypermobility, atrophic scarring, and blood vessel fragility. Complications include joint dislocation, chronic pain, fatigue, functional ga…
Challenges in Offloading Lesser Toe Deformities: A Case Study.
Lesser toe deformities such as hammer, mallet, claw, or cross over toe deformities are common in the elderly. They are attributed to mechanical, neuromuscular, congenital, inflammatory arthritis, or other disorders. They become clinically relevant when they produce pressure and friction at the dista…
Spinal Deformity Characteristics Associated With Intraspinal Anomalies in a Population of Presumed Adolescent Idiopathic Scoliosis (AIS).
Intraspinal anomalies (IA) are reported to occur in 7% to 19% of patients undergoing surgery for adolescent idiopathic scoliosis (AIS). However, these studies have not focused on IA that require neurosurgical intervention and have not assessed whether deformity characteristics predict their underlyi…
Challenges Experienced by Patients With Chronic Venous Disease in Unresolved Postoperative Recovery After Iliac Vein Stenting: A Phenomenological Study.
Previous researchers have mainly examined the general recovery of patients with chronic venous disease after iliac vein stent placement for iliac vein compression syndrome. However, little is known about the specific challenges faced by patients who remain in an unresolved postoperative recovery pha…
A hydrogel ionic circuit electrical stimulation system to restore denervated muscle following long-gap peripheral nerve injury.
Electrical stimulation (EStim) has been used to exercise denervated muscle pending nerve regeneration, to prevent muscle atrophy. However, higher EStim intensity is required to achieve maximal therapeutic efficacy, which is challenging because conventional electrodes generate heat and alter pH, pote…
Baicalein solid dispersion prepared by solvent evaporation enhances oral bioavailability and alleviates ulcerative colitis.
Baicalein (BAC) is a flavonoid compound known for its effectiveness in treating ulcerative colitis (UC). However, its clinical application is limited by poor water solubility, low stability, and low oral bioavailability. In this study, a baicalein solid dispersion (BAC-SD) was prepared using Polyvin…
Clinical transitions amid rapid expansion: a 16-year retrospective analysis of ultrasound-guided high-intensity Focused ultrasound (USgHIFU) for uterine fibroids and adenomyosis in Korea and the necessity for clinical standardization.
Since its introduction in 2010, Ultrasound-guided High-Intensity Focused Ultrasound (USgHIFU) has rapidly expanded in South Korea, despite the absence of widely accepted standardized clinical protocols. This study evaluated the long-term clinical outcomes of USgHIFU and proposed a standardized MRI-i…
Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study.
Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and progesterone receptor (PR) signaling landscape is poorly defi…
Causal effect of thyroid function on cortical brain structure: A two-sample Mendelian randomization study.
The causal relationship between variations in thyroid dysfunction and brain structure remains elusive. We intended to probe into this causal connection using a Mendelian randomization (MR) approach. Aggregated statistics from the genome-wide Association Study (GWAS) on Autoimmune thyroid dysfunction…
Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.
Granulomas can be found in different tissues and are associated with a variety of processes. To understand the primary diagnoses is the aim of this study. We retrospectively described a cohort of patients with a diagnosis of granulomas in histopathological samples over an 11-year period. Demographic…
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