Commensal microbiota-coated biohybrid implants induce antibiofilm, osteogenic, and immunomodulatory responses in a human 3D immunocompetent model.
Medical devices have revolutionized patient care; however, their abiotic surfaces remain highly susceptible to bacterial biofilm formation, enabling immune evasion and antibiotic resistance. Although antibacterial coatings can mitigate bacterial colonization, many rely on antimicrobial agents that m…
Sebetralstat for breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis in KONFIDENT-S.
Although long-term prophylaxis (LTP) reduces attack frequency in hereditary angioedema, patients may experience breakthrough attacks. Oral sebetralstat demonstrated favorable safety and efficacy compared with placebo in the randomized phase 3 KONFIDENT trial (NCT05259917), including in patients rece…
Clinical expressions, disease course, quality of life, and resilience in subgroups of patients with angioedema.
Patients with angioedema caused by C1INH deficiency (HAE-C1INH) experience recurrent episodes of unpredictable swelling. Recently, new genetic variants have been identified, whereas patients with unknown causes and no identifiable genetic mutations constitute a distinct subgroup. As a lifelong condi…
Improving capability, opportunity and motivation to support hereditary angioedema patients experiencing life threatening attacks: Pilot evaluation of a video-based training tool for healthcare professionals.
Hereditary angioedema (HAE) is a rare inherited illness which causes swelling and can be life-threatening without urgent treatment. Patients who experience life-threatening throat swellings report poor emergency care experiences and long-term psychological distress from these encounters. A >&#x…
Thoracoscopic Segmentectomy for Pulmonary Sequestration Supplied by Aberrant Celiac Trunk.
Pulmonary sequestration is a congenital anomaly: nonfunctioning lung tissues receive systemic arterial supply without bronchial communication. Aberrant arteries mainly arise from the descending thoracic aorta, whereas those originating from the celiac trunk are uncommon. We report the case of a woma…
Phosphodiesterase-5 inhibitors, but not calcium channel blockers, improve peripheral vascular function in systemic sclerosis.
Systemic sclerosis (SSc) is a rare autoimmune disease associated with vasculopathy. Raynaud's phenomenon is a common symptom of SSc, and treatment guidelines support calcium channel blocker (CCB) and phosphodiesterase inhibitor-5 (PDE5i) as first- and second-line therapy, respectively. However, the…
Evaluation of a modified next-generation sequencing assay to detect Borrelia, Anaplasma, and Babesia in blood and ear tissue samples from field-collected rodents.
Efforts to monitor the expanding geographic distribution of pathogens associated with Ixodes scapularis Say (Acari: Ixodidae), and to evaluate the outcomes of environmental control interventions aiming to reduce the intensity of enzootic transmission of these pathogens, are dependent on sensitive an…
We report a case of a kidney transplant recipient who presented with generalised muscle pain, weakness and brown urine discoloration in the setting of acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Investigations demonstrated rhabdomyolysis with elevated creatine kinas…