A neurological disease characterised by recurring severe headaches often accompanied by nausea, light and sound sensitivity.
✦ AI summary
Migraine is described as one of the most common neurological disorders and a leading cause of disability worldwide, with a large global burden of illness measured in disability-adjusted life years [4]. Several treatment approaches are being studied: nerve decompression/combing surgery for related occipital pain conditions has shown large reductions in pain days and medication use in one retrospective study [2], nerve block injections (occipital, and combined occipital-supraorbital) reduced headache frequency, severity, and disability scores in chronic migraine patients [9], and a new intranasal dihydroergotamine powder (STS101) showed possible benefit at later timepoints though it did not meet its main early trial goal [10]. Research also explores newer mechanisms, such as an herbal decoction's nanoparticle components affecting serotonin release and inflammatory signaling in migraine models [5], and TRPA1 receptor blockers showing preclinical pain-reducing effects in migraine-like models [8]. On the diagnostic side, sources highlight confusion between migraine-related conditions like status migrainosus, new daily persistent headache, and refractory migraine due to overlapping definitions [7], and note that migraine can be a comparison condition in research on other headache-causing
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Severe headacheNauseaLight sensitivitySound sensitivityAuraFatigue
Safety monitoring of bivalent, quadrivalent, and 9-valent human papillomavirus vaccination in Japan: The vaccine effectiveness, networking, and universal safety (VENUS) study.
Safety data on human papillomavirus (HPV) vaccination in the Japanese population remain limited owing to the lack of healthcare databases available for vaccine safety assessment. In this study, we assessed the risk of adverse events of special interest (AESIs) following HPV vaccination among females…
Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
The burden of noncommunicable and injury-related nervous system disorders in the Americas, 1990-2023: an analysis of the Global Burden of Disease Study 2023.
Noncommunicable and injury-related nervous system disorders (NINSDs)-including cerebrovascular and neurodegenerative diseases, neurodevelopmental disorders, neuromuscular conditions, brain cancers, and traumatic brain injuries-are major contributors to morbidity, disability, and premature mortality…
When does empathy help? Patient-perceived physician empathy and migraine severity.
Migraine is one of the most common neurological disorders and the second leading cause of disability worldwide. While it is known that psychosocial factors play an important role in illness, it is not clear how they are related to patients' perceptions of clinician empathy. We aimed to examine the r…
A comparison of the effects of greater occipital nerve blockade and combined greater occipital-supraorbital nerve blockade on headache in chronic migraine.
To evaluate and compare the effects of isolated greater occipital nerve (GON) blockade versus combined GON-supraorbital nerve (SON) blockade on headache severity, frequency, duration, and quality of life in patients with chronic migraine. This retrospective study included 80 patients with CM who had…
Self-assembled nanoaggregates in Wuzhuyu decoction: formation, absorption, transport, and alleviation of chronic migraine.
Self-assembled nanoaggregates (SANs) derived from herbal decoctions have emerged as promising natural nanomedicines. However, their formation patterns in multi-herb formulations and therapeutic roles in central nervous system disorders remain unclear. Wuzhuyu decoction (WZYD) is a classical formula…
STS101 nasal powder as a new treatment option for acute migraine with or without aura in adults.
Although effective acute migraine therapies are available, unmet treatment needs such as nausea, vomiting, or delayed gastric emptying remain. STS101 is a novel dihydroergotamine (DHE) nasal powder designed to treat acute migraine with a simple single. A targeted PubMed and ClinicalTrials.gov search…
Burden among participants with central disorders of hypersomnolence in six European countries.
Narcolepsy types 1 and 2 (NT1/NT2) and idiopathic hypersomnia (IH) are central disorders of hypersomnolence (CDHs) that significantly impact patients' quality of life (QoL). We investigated the recent medication use, comorbidities, and clinical burden among participants with CDHs from six European c…