Crohn's is a chronic inflammatory bowel disease causing inflammation anywhere in the GI tract.
✦ AI summary
These sources touch on Crohn's disease mainly as part of the broader category of inflammatory bowel disease (IBD), rather than focusing on Crohn's specifically:
- **Diagnosis-related findings:** When doctors examine tissue samples for granulomas (a pattern of inflammation), IBD is one of the leading causes found, especially in Western European patients, where it was the top diagnosis for this finding [1]. Researchers are also working on standardizing gut microbiota ("dysbiosis") testing, and have found this can be done consistently across different countries for people with IBD and related conditions [2]. Separately, pathologists are refining how they classify unusual patterns of precancerous changes (dysplasia) in IBD tissue, since these patterns can signal higher future cancer risk and need careful, reproducible evaluation [6].
- **Related complications and care needs:** People with IBD are more prone to certain infections, such as *C. difficile*, and managing this is complicated by diagnostic uncertainty [5]. Older adults with IBD face added risks of physical decline, and research suggests structured exercise and physical therapy—though underused—may help with joint pain, fatigue, and post-surgery recovery [3]. Children with
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.
Granulomas can be found in different tissues and are associated with a variety of processes. To understand the primary diagnoses is the aim of this study. We retrospectively described a cohort of patients with a diagnosis of granulomas in histopathological samples over an 11-year period. Demographic…
The Roles of Complementary Structured Exercise and Physical Therapy in The Aging and Older Adult IBD Patient Care Team.
Structured exercise (SE) and physical therapy (PT) are integral components of disease management. Older adults with inflammatory bowel disease (IBD) represent a growing proportion of patients, and are at disproportionate risk of functional decline due to the combined effects of aging, chronic inflam…
Towards standardized gut microbiota diagnostics: normobiosis beyond geographical borders.
Defining clinically meaningful reference states of the human gut microbiota remains a major barrier to the clinical translation of microbiome testing, largely due to variability across populations. We aimed at evaluating whether dysbiosis can be identified in a standardized, geography-independent ma…
HSP27 in autoimmune diseases: Context-dependent regulation and clinical potential.
Heat shock protein 27 (HSP27) is a crucial member of the small heat shock protein family with a molecular weight of approximately 27 kDa, playing key roles in cellular stress response, protein homeostasis, and cell survival regulation. Recent studies have revealed that HSP27 plays a complex dual rol…
Diagnostic Significance and Reproducibility of Non-conventional Dysplasia and Serrated Epithelial Change in Inflammatory Bowel Disease.
Although most dysplastic lesions in inflammatory bowel disease resemble sporadic adenomas, several distinct morphologic patterns, collectively termed non-conventional dysplasia, have recently been described. Accurate evaluation of these lesions is essential, as many are endoscopically invisible or f…
TTC7A deficiency: A retrospective international study on treatment and outcomes from the Inborn Errors Working Party of EBMT.
Tetratricopeptide repeat domain 7A (TTC7A) deficiency is a primary immunodeficiency due to mutations in the TTC7A gene. It causes intestinal disease and a poorly characterized immunodeficiency, with poor long-term survival. We describe the clinical and immunological characteristics, management, and…
Management of Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease.
Clostridioides difficile is a gram-positive, anaerobic bacteria that is ubiquitous. Oral-fecal transmission of the organism and its spores leads to C difficile colonization and infection (CDI) within the human gastrointestinal tract. Patients with inflammatory bowel disease (IBD) are more likely to…
Long-term rheumatologic comorbidities in familial Mediterranean fever.
Familial Mediterranean fever (FMF) is characterized by pyrin inflammasome dysregulation and chronic subclinical inflammation. Whether FMF carries an increased long-term burden of rheumatologic and autoimmune inflammatory disease is unclear. We evaluated baseline and long-term occurrence of rheumatol…