A condition where the uterine lining grows into the muscle wall of the uterus, causing heavy, painful periods.
✦ AI summary
Adenomyosis is a uterine condition linked to heavy menstrual bleeding, painful periods, and reduced quality of life, and research suggests it may develop from repeated tiny injuries to the uterine lining over many menstrual cycles, with more lifetime periods associated with more severe disease on ultrasound [5]. Studies exploring symptom patterns found that people with adenomyosis tend to have higher pain and disease burden compared with some other groups, with no truly symptom-free subgroup identified [8]. For fertility, one study found adenomyosis didn't significantly lower overall live birth rates in donor-egg IVF cycles overall, but disease located in both the outer muscle layer and inner uterine wall was linked to lower success and needing more embryo transfer attempts [7]. On treatment, various uterus-preserving options are being studied, including focused ultrasound ablation with long-term symptom control in many patients [1], combined hormonal and surgical approaches for cases that don't respond well to ultrasound treatment [3], intrauterine devices designed to stay in place better in people with adenomyosis [4], newer oral hormone-suppressing medications that appear promising but are described as controlling rather than curing the condition [6],
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Heavy periodsPelvic painBloatingFatiguePainful intercourseAnaemia
Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study.
Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and progesterone receptor (PR) signaling landscape is poorly defi…
Clinical transitions amid rapid expansion: a 16-year retrospective analysis of ultrasound-guided high-intensity Focused ultrasound (USgHIFU) for uterine fibroids and adenomyosis in Korea and the necessity for clinical standardization.
Since its introduction in 2010, Ultrasound-guided High-Intensity Focused Ultrasound (USgHIFU) has rapidly expanded in South Korea, despite the absence of widely accepted standardized clinical protocols. This study evaluated the long-term clinical outcomes of USgHIFU and proposed a standardized MRI-i…
Efficacy and safety of combined GnRH-a, hysteroscopic surgery, and LNG-IUS for adenomyosis with suboptimal HIFU ablation: a retrospective study.
To evaluate the safety and efficacy of sequential combination therapy comprising gonadotropin-releasing hormone agonist (GnRH-a), hysteroscopic surgery (residual lesion resection plus endometrial ablation), and levonorgestrel-releasing intrauterine system (LNG-IUS) insertion in patients with adenomy…
Clinical efficacy and safety of indomethacin-gyneFix IUD combined with a levonorgestrel-releasing intrauterine system in patients with adenomyosis and different uterine cavity depths.
Adenomyosis is commonly associated with dysmenorrhea and heavy menstrual bleeding. Although the levonorgestrel-releasing intrauterine system (Mirena, LNG-IUS) is recommended as a first-line conservative treatment, device displacement or expulsion remains a major limitation, especially in patients wi…
A hypothesis on the aetiology of adenomyosis: is there an association between cumulative number of menstruations and severity of adenomyosis on ultrasound?
Adenomyosis is a common uterine disorder, yet its aetiology remains debated. The tissue injury and repair (TIAR) hypothesis suggests that repeated microtrauma from menstrual contractions damages the endometrial-myometrial interface, thereby contributing to development and progression of adenomyosis.…
Effect of adenomyosis on the cumulative live birth rate in oocyte donation cycles: a retrospective analysis.
What is the effect of adenomyosis on cumulative live birth rate (CLBR) in women undergoing single embryo transfer in donor-oocyte cycles, with specific attention to type, location and severity of disease. Retrospective observational study of 228 infertile women treated at IVI Roma between 2019 and 2…
Preclinical models of female pelvic pain disorders.
Pain is influenced by a complex interplay of biological, psychological, and social factors. Sex has emerged as a key determinant of vulnerability to chronic pain and a major risk factor for poor response to available pharmacological treatments. Women report higher rates of chronic pain and exhibit g…
Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the All of Us Research Program.
Are there distinct symptom clusters in women with endometriosis and adenomyosis, and how do these clusters predict quality of life? Latent class analyses of 22 438 women with endometriosis identified four symptom phenotypes, including high pain-gastrointestinal and psychological-neurological cluster…