Abnormal expression of galectins and their correlation with fibrogenesis in adenomyosis.
This cross-sectional study investigated galectin-1, -3, and -9 in adenomyosis. Analysis of hysterectomy tissues from premenopausal women via western blot, qPCR, immunohistochemistry, and Masson's staining revealed significantly elevated galectin levels compared to controls. Galectin expression posit…
Elevated ESR2 and BRCA1 gene expression in adenomyosis associated with endometrial cancer: a pilot study.
Adenomyosis is a benign uterine disease that has been associated with endometrial proliferative disorders. Adenomyosis and endometrial cancer (EC) are sex-steroid-dependent conditions that may coexist, but their estrogen receptor (ER) and progesterone receptor (PR) signaling landscape is poorly defi…
A hypothesis on the aetiology of adenomyosis: is there an association between cumulative number of menstruations and severity of adenomyosis on ultrasound?
Adenomyosis is a common uterine disorder, yet its aetiology remains debated. The tissue injury and repair (TIAR) hypothesis suggests that repeated microtrauma from menstrual contractions damages the endometrial-myometrial interface, thereby contributing to development and progression of adenomyosis.…
Profiling of serum IgG1 Fc‑glycosylation and tissue bisecting GlcNAc in adenomyosis.
Adenomyosis (AM) commonly affects women of reproductive age and can impair female fertility, yet its diagnosis and pathogenesis remain challenging. We compared serum IgG1 Fc‑glycosylation profiles between AM patients (n = 30) and non‑AM controls (n = 16). IgG concen…
The endometriosis-adenomyosis spectrum: shared pathophysiology and microenvironment-driven disease divergence.
Endometriosis and adenomyosis are common gynecologic disorders associated with dysmenorrhea, chronic pelvic pain, and infertility. Although they share several molecular features, the mechanisms by which endometrium-derived tissues develop distinct pathological phenotypes in different tissue environm…
GyneFix levonorgestrel-releasing intrauterine system for Chinese patients: a preliminary retrospective self-controlled observational study.
Device expulsion is a common complication of the levonorgestrel-releasing intrauterine system (LNG-IUS), with a higher incidence among high-risk patients presenting with enlarged uterine cavities, cervical laxity or menorrhagia. At present, no commercially available frameless LNG-IUS is marketed in…
Adenomyosis is not an independent prognostic factor in endometrioid-type endometrial cancer.
The prognostic significance of adenomyosis in endometrial cancer (EC) remains controversial. Although several studies have suggested an association between adenomyosis and favorable tumor characteristics or improved survival outcomes, it remains unclear whether this relationship persists after adjus…
Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the All of Us Research Program.
Are there distinct symptom clusters in women with endometriosis and adenomyosis, and how do these clusters predict quality of life? Latent class analyses of 22 438 women with endometriosis identified four symptom phenotypes, including high pain-gastrointestinal and psychological-neurological cl…