What helps? Patient-reported strategies for managing functional/dissociative seizures: a cross-sectional survey.
The value of incorporating lived experience into research is increasingly recognised, however, traditional functional/dissociative seizure (FDS) treatment studies assess treatment efficacy prior to ascertaining real-world effectiveness. This study aimed to gather firsthand accounts from individuals…
Mega-analysis of Structural Brain Imaging in Functional Neurological Disorder.
Despite recent advances, the pathophysiology of functional neurological disorder (FND) remains incompletely understood. Structural neuroimaging studies have identified grey matter alterations in somatomotor, salience, limbic, and default mode network associated areas, although findings are inconsist…
Dynamics of the systemic inflammatory response surrounding stressors and the association with neuropsychiatric and somatic outcomes.
Acute and chronic stressors contribute to neuropsychiatric disorders. However, the role of inflammatory dynamics around stress exposure remains unclear. Using TriNetX, an international electronic health records database, we examined how systemic inflammatory activity and its temporal dynamics relate…
Identifying unique gait phenotypes across neuromotor conditions using wearable inertial sensors and topological data analysis.
Wearable sensors quantify gait and mobility in detail, but translating high-dimensional data into clinically actionable insights remains challenging in precision rehabilitation. We applied Topological Data Analysis (TDA) to inertial sensor recordings from multiple gait assessments in 81 individuals…
Diagnostic Agreement and 1-Year Outcomes in Functional Neurological Disorder Following Neuroscience-Informed Assessment, Education, and Counseling: A Retrospective Cohort Study.
We sought to explore outcomes at 1 year in functional neurological disorder (FND) following a neuroscience-informed education and counseling assessment. Patients with FND were assessed at a quaternary neuropsychiatry clinic in Toronto, Canada, and provided education and counseling to build insi…
[Clinical management of headache comorbid with functional neurological disorder].
Headache, particularly migraine, is highly prevalent in patients with functional neurological disorder (FND) but is often underrecognized in clinical practice. This review provides an overview of the existing literature on the association between FND and headache and demonstrates that comorbid migra…