PSC is a rare liver disease causing chronic inflammation and scarring of the bile ducts.
✦ AI summary
Primary sclerosing cholangitis (PSC) is a long-term liver condition where the bile ducts become inflamed and scarred over time, and research describes it as an autoimmune-type disease often linked to gut and immune system factors [2][6]. Studies point to disturbances in bile acids and inflammatory markers (like IP-10) that may be tied to worsening liver scarring [4], and broader "multi-omic" studies (looking at proteins, metabolites, and genetic markers in blood) suggest that people with more severe PSC show biological changes that overlap with those seen in bile duct cancer (cholangiocarcinoma), hinting that cancer-related processes may start early in the disease [6]. Because PSC carries a notable risk of developing bile duct cancer, especially in the perihilar (central) bile ducts, research is exploring better detection tools and treatments, including chemotherapy/radiation followed by liver transplant in eligible patients [9], as well as lab-based work into potential drug targets like ANXA2, inspired by a traditional herbal compound (quercetin) [3]. One clinical study found that people with PSC who took vitamin D supplements had a notably lower rate of developing hepatobiliary cancer comp
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
FatigueItchingJaundiceAbdominal painFeverWeight loss
Examining Cost Differences in Malignant Brain and Central Nervous System Tumor Treatment Across US Military Health System Care Settings.
The objectives of this study were to determine whether the cost of care for malignant brain and other central nervous system tumors (MBT) in the US Military Health System differs between the Department of War-operated direct care (DC) network and the affiliated civilian-operated private sector care…
Annexin A2 as a therapeutic target of Artemisiae Scopariae Herba-derived quercetin in preventing malignant progression from primary sclerosing cholangitis to cholangiocarcinoma: An integrative study.
Artemisiae Scopariae Herba (ASH) is traditionally used to treat cholestatic liver diseases and exhibits anti-tumour potential. Cholangiocarcinoma (CCA) and its major risk factor, primary sclerosing cholangitis (PSC), lack effective therapies. In this study, we aimed to elucidate the bioactive consti…
Environmental shaping of tolerance failure in autoimmune liver diseases: a phenotype-specific framework with primary biliary cholangitis as the strongest model.
Autoimmune liver diseases (primary biliary cholangitis, PBC; primary sclerosing cholangitis, PSC; autoimmune hepatitis, AIH) are three distinct, organ-specific autoimmune disorders that share loss of tolerance as the central pathophysiological mechanism but differ in target tissue, age of onset, gen…
Interferon-gamma-inducible protein-10 is associated to increased primary bile acids and fibrosis in primary sclerosing cholangitis.
Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts. Altered bile acid (BA) profile was shown to trigger immune responses in the liver, contributing to inflammation and liver fibrosis. Here, we analyzed…
Diagnostic Significance and Reproducibility of Non-conventional Dysplasia and Serrated Epithelial Change in Inflammatory Bowel Disease.
Although most dysplastic lesions in inflammatory bowel disease resemble sporadic adenomas, several distinct morphologic patterns, collectively termed non-conventional dysplasia, have recently been described. Accurate evaluation of these lesions is essential, as many are endoscopically invisible or f…
Examining the role of dipeptidyl peptidase IV (DPPIV) in psoriatic disease.
Chemokine CXCL10 plays an important role in PsA, an inflammatory arthritis associated with psoriasis. CXCL10 is post-translationally regulated by dipeptidyl peptidase-4 (DPPIV). The objectives of this study were to measure levels of DPPIV, CXCL10 and DPPIV enzyme activity (EA) in patients with PsA,…
Vitamin D supplementation is associated with reduced risk of hepatobiliary malignancy in patients with primary sclerosing cholangitis.
Vitamin D deficiency has been implicated in cancer risk across several organ systems, but its role in hepatobiliary malignancy (HBM) remains unclear. We evaluated whether vitamin D supplementation (VDS) was associated with a lower risk of HBM specifically in patients with primary sclerosing cholangi…
Proximally dominant inflammation at colonoscopy predicts pan-colonic histological remission following oral vancomycin therapy in pediatric ulcerative colitis.
Oral vancomycin therapy (OVT) induces histological remission in children with ulcerative colitis (UC) showing primary sclerosing cholangitis (PSC)-associated features (proximally dominant or patchy inflammation, backwash ileitis, or rectal sparing). However, predictors of response and optimal treatm…