Small Fiber Neuropathy

A condition affecting the small sensory nerve fibres, causing burning pain, numbness, and autonomic dysfunction.

✦ AI summary

Here's what these sources say about Small Fiber Neuropathy (SFN): **What it is and how it's diagnosed:** SFN affects the thin sensory and autonomic nerve fibers (called Aδ and C fibers) that help sense pain, temperature, and itch, and that control automatic body functions like sweating, digestion, heart rate, and bladder function [7]. It's described as common but often challenging to diagnose and treat [6]. The gold-standard test is measuring nerve fiber density in a skin biopsy, and researchers have worked on establishing accurate normal reference values by age and sex to improve diagnostic accuracy [2]. Other tools used include corneal nerve imaging [9], sensory/autonomic testing, and clinical examination [7][11]. In cases linked to hereditary conditions like transthyretin amyloidosis, specialized lab techniques on skin biopsies can help identify the specific protein causing nerve damage [4]. **Causes:** Diabetes is noted as the most common cause [6], and SFN can also occur with genetic channel abnormalities (channelopathies) that affect pain signaling [6][8]. One case report describes SFN occurring in an adolescent with Prader-

This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.

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