A functional gastrointestinal disorder causing chronic abdominal pain and altered bowel habits.
✦ AI summary
Here's what this set of sources covers on Irritable Bowel Syndrome (IBS): IBS is classified as a "disorder of gut-brain interaction," and research links it to gut microbiota imbalances ("dysbiosis"), immune activation, and visceral hypersensitivity (increased sensitivity to gut sensations) [1][6][12]. Large population studies suggest environmental factors earlier in life, like childhood farm exposure, are associated with somewhat higher odds of IBS, while certain adulthood living conditions were linked to lower odds — though these are statistical associations, not proven causes [6]. Separately, some research finds people with IBS screen higher for avoidant/restrictive eating patterns (limiting food intake due to fear of symptoms like pain), more so than in some other GI conditions [8]. On management, sources describe several approaches under study or in use: medications like tenapanor for IBS with constipation showed symptom improvement in trial data, including in people who'd already tried other prescription treatments [7]; dietary adjustments (such as restricting certain fermentable carbohydrates) and bowel-focused physical therapy are mentioned for constipation-with-bloating, a pattern that overlaps with IB
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