A neuromuscular disorder causing muscle weakness that worsens with activity and improves with rest.
✦ AI summary
The sources here only touch on Myasthenia Gravis (MG) from a few narrow angles, not a broad overview:
- One report describes an unusual case where a woman without prior MG developed both chylothorax (a rare fluid-drainage complication) and a serious myasthenic crisis after thymus-removal surgery (thymectomy) for thymoma, showing that MG can newly emerge after this type of surgery and may require intensive care, including corticosteroids, other immune-modulating medications, plasma exchange, and breathing support [11].
- An international panel of MG experts used a formal consensus method to agree on 21 recommendations for "comprehensive care" of MG patients, with the overall goal being to help patients reach and maintain minimal symptoms and side effects while preserving quality of life; specific topics included early symptom control, vaccination/infection screening, family planning and pregnancy, managing fatigue and other co-existing conditions, and preparing for or managing a myasthenic crisis [12].
- A broader review of a protein called HSP27 in autoimmune diseases lists myasthenia gravis among several autoimmune conditions studied, noting that HSP27 has complex, disease-specific immune-regulating effects, though the source
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Nocturnal sleep-related scratching disorder as a possible variant of NREM arousal disorder: Clinical features and polysomnographic study of four newly reported cases.
A clinical variant of NREM arousal disorder is described manifesting with predominantly injurious, and exclusively sleep-related scratching without any conscious awareness, and without a history of dermatologic disease. Four patients were clinically evaluated and underwent videopolysomnography (vPSG…
Glehnia littoralis and imperatorin attenuate allergic airway inflammation via mast cell stabilization and transcriptome-defined suppression of FcεRI/TLR-MAPK/NF-κB signaling.
Allergic airway inflammation is driven by mast cell activation and IgE-FcεRI signaling. Current pharmacological treatments often present limited efficacy or long-term adverse effects. Glehnia littoralis Fr. Schmidt ex Miq. (GL) is a traditional medicinal herb used for respiratory ailments, but its a…
Comparison of the efficacy of varespladib and coral snake antivenom against the activities of the Amazon coral snake (Micrurus spixii) venom.
The ability of varespladib (VPL), a phospholipase A2 (PLA2) inhibitor, to attenuate several activities of the Amazon coral snake (Micrurus spixii) venom was assessed. The neutralization by VPL was compared to that of coral snake antivenom and, in some cases, neostigmine. The venom showed anticoagula…
Percutaneous balloon compression followed by perineural methylprednisolone for trigeminal neuralgia: A 50-patient retrospective series with 12-month outcomes.
To describe pain outcomes and safety after a combined protocol of percutaneous balloon compression (PBC) followed immediately by perineural methylprednisolone in adults with pharmacoresistant trigeminal neuralgia. We conducted a multicentre, single-arm, retrospective observational series without a c…
Persistent deficits in the motor unit following mono and dual administration of SMN up-regulators in the SmnΔ7 mouse model of spinal muscular atrophy.
Spinal muscular atrophy (SMA) is characterized by motor neuron loss and neuromuscular junction (NMJ) pathology. Although SMN-upregulating therapies such as Nusinersen markedly improve survival and motor function for many patients, impactful deficits often remain. In order to generate the next genera…
HSP27 in autoimmune diseases: Context-dependent regulation and clinical potential.
Heat shock protein 27 (HSP27) is a crucial member of the small heat shock protein family with a molecular weight of approximately 27 kDa, playing key roles in cellular stress response, protein homeostasis, and cell survival regulation. Recent studies have revealed that HSP27 plays a complex dual rol…
Impaired Motor Function in a Zebrafish Stathmin-2 Knockout Model.
Stathmin-2 (STMN2) is a microtubule-associated protein that plays a role in the stability of microtubules in axons of the nervous system of animals. In this study, we generated a novel zebrafish STMN2 knockout (KO) model. STMN2 is represented by two genes in the zebrafish genome: stmn2a and stmn2b.…
Peripheral nervous system involvement in Parkinson's disease: Peripheral neuropathy, neuromuscular junction dysfunction, and clinical implications.
Parkinson's disease (PD) has long been recognized as a central nervous system disorder, yet growing evidence indicates that the peripheral nervous system (PNS) plays a clinically relevant role in disease initiation, progression and heterogeneity. Peripheral sensory, autonomic, and motor pathways, in…