Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double-Blind Trial.
Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients. The aim of this study was…
Sebetralstat for breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis in KONFIDENT-S.
Although long-term prophylaxis (LTP) reduces attack frequency in hereditary angioedema, patients may experience breakthrough attacks. Oral sebetralstat demonstrated favorable safety and efficacy compared with placebo in the randomized phase 3 KONFIDENT trial (NCT05259917), including in patients rece…
Phenotype, Severity, and Therapy of Patients With LRP4 Antibody-Associated Myasthenia Gravis in the German Myasthenia Gravis Registry.
Lipoprotein receptor-related protein 4 antibody-positive myasthenia gravis (LRP4-Ab-positive MG) is a rare serologic subgroup with poorly defined clinical phenotype. This study investigated demographics, clinical features, treatments, and disease burden of LRP4-Ab-positive MG against other antibody-…
Comprehensive Care Goals in Myasthenia Gravis: Expert Consensus Recommendations Using the RAND/UCLA Appropriateness Method.
Goals for comprehensive care are important in the management of individualized treatment for patients with myasthenia gravis (MG), a disease with variable presentation and degrees of severity. Yet there is limited guidance on how comprehensive care should be achieved and implemented. We present glob…
Single-Dose Nivolumab as a Trigger of Myocarditis, Myositis, and Myasthenia Gravis Overlap Syndrome With Late Cardiac Death Despite Initial Recovery: A Case Report.
BACKGROUND Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced malignancies but can cause life-threatening immune-related adverse events. Myocarditis, myositis, and myasthenia gravis (MMM) overlap syndrome is a rare, highly morbid complication with high mortality. Most cas…
Association Between the Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Perioperative Mortality Risk in Myasthenia Gravis Patients with Sepsis: A Retrospective Cohort Study.
BackgroundThis study aims to explore the association between the Hemoglobin/Red Cell Distribution Width Ratio (HRR) and perioperative mortality in myasthenia gravis (MG) patients with sepsis based on the electronic ICU collaborative research database (eICU-CRD).MethodsWe retrospectively analyzed dat…
Left Main Spontaneous Coronary Artery Dissection in a Young Woman With Migraine and Triptan Use.
Spontaneous coronary artery dissection (SCAD) results from intramural hematoma formation within the coronary arterial wall. It predominantly affects young women and is associated with physical or emotional stress, hormonal influences, and vasoactive medications. A 33-year-old woman presented to the…
Coexistence of acromegaly and raised intracranial pressure: insights from a rare case report and literature review.
Idiopathic intracranial hypertension (IIH) is a rare condition characterized by increased cerebrospinal fluid pressure without an intracranial mass, mainly affecting overweight women of reproductive age. It commonly presents with headache, visual disturbance, and papilledema. Acromegaly is an uncomm…