Nocturnal sleep-related scratching disorder as a possible variant of NREM arousal disorder: Clinical features and polysomnographic study of four newly reported cases.
A clinical variant of NREM arousal disorder is described manifesting with predominantly injurious, and exclusively sleep-related scratching without any conscious awareness, and without a history of dermatologic disease. Four patients were clinically evaluated and underwent videopolysomnography (vPSG…
Glehnia littoralis and imperatorin attenuate allergic airway inflammation via mast cell stabilization and transcriptome-defined suppression of FcεRI/TLR-MAPK/NF-κB signaling.
Allergic airway inflammation is driven by mast cell activation and IgE-FcεRI signaling. Current pharmacological treatments often present limited efficacy or long-term adverse effects. Glehnia littoralis Fr. Schmidt ex Miq. (GL) is a traditional medicinal herb used for respiratory ailments, but its a…
Percutaneous balloon compression followed by perineural methylprednisolone for trigeminal neuralgia: A 50-patient retrospective series with 12-month outcomes.
To describe pain outcomes and safety after a combined protocol of percutaneous balloon compression (PBC) followed immediately by perineural methylprednisolone in adults with pharmacoresistant trigeminal neuralgia. We conducted a multicentre, single-arm, retrospective observational series without a c…
Persistent deficits in the motor unit following mono and dual administration of SMN up-regulators in the SmnΔ7 mouse model of spinal muscular atrophy.
Spinal muscular atrophy (SMA) is characterized by motor neuron loss and neuromuscular junction (NMJ) pathology. Although SMN-upregulating therapies such as Nusinersen markedly improve survival and motor function for many patients, impactful deficits often remain. In order to generate the next genera…
Impaired Motor Function in a Zebrafish Stathmin-2 Knockout Model.
Stathmin-2 (STMN2) is a microtubule-associated protein that plays a role in the stability of microtubules in axons of the nervous system of animals. In this study, we generated a novel zebrafish STMN2 knockout (KO) model. STMN2 is represented by two genes in the zebrafish genome: stmn2a and stmn2b.…
Comparison of the efficacy of varespladib and coral snake antivenom against the activities of the Amazon coral snake (Micrurus spixii) venom.
The ability of varespladib (VPL), a phospholipase A2 (PLA2) inhibitor, to attenuate several activities of the Amazon coral snake (Micrurus spixii) venom was assessed. The neutralization by VPL was compared to that of coral snake antivenom and, in some cases, neostigmine. The venom showed anticoagula…
HSP27 in autoimmune diseases: Context-dependent regulation and clinical potential.
Heat shock protein 27 (HSP27) is a crucial member of the small heat shock protein family with a molecular weight of approximately 27 kDa, playing key roles in cellular stress response, protein homeostasis, and cell survival regulation. Recent studies have revealed that HSP27 plays a complex dual rol…
Peripheral nervous system involvement in Parkinson's disease: Peripheral neuropathy, neuromuscular junction dysfunction, and clinical implications.
Parkinson's disease (PD) has long been recognized as a central nervous system disorder, yet growing evidence indicates that the peripheral nervous system (PNS) plays a clinically relevant role in disease initiation, progression and heterogeneity. Peripheral sensory, autonomic, and motor pathways, in…