Complex Regional Pain Syndrome

CRPS is a chronic pain condition usually affecting a limb, characterised by severe burning pain and sensitivity.

✦ AI summary

Complex Regional Pain Syndrome (CRPS) is described as a disabling, hard-to-treat condition involving pain that can be neuropathic, nociceptive, or mixed, along with sensory changes, swelling, and reduced function [3][9]. Research into treatments is mixed: gabapentin and physiotherapy have the strongest evidence among reviewed options, while many other drugs and therapies (like acupuncture, mirror therapy, or spinal cord stimulation) have weaker or inconsistent support [3][9]. Some newer or experimental approaches show promise in small studies — a case report found weekly ketamine infusions gave temporary pain reduction in a treatment-resistant case [4], a trial testing mesotherapy (skin injections) with lidocaine and ketamine found no added benefit over lidocaine alone [6], and animal research suggests a drug blocking a specific immune signaling pathway (JAK-STAT) reduced pain-like behavior and immune markers in a mouse model of CRPS, pointing to a possible immune-system role in the condition [8]. A review of physiological studies found some measurable differences between CRPS-affected and unaffected limbs, but noted these were often similar to effects of

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