MCTD is an overlap autoimmune disease combining features of lupus, scleroderma, and polymyositis.
✦ AI summary
Here's what these sources cover on Mixed Connective Tissue Disease (MCTD):
- **Pregnancy risks**: A large Nordic register study found MCTD pregnancies (along with other autoimmune diseases) had notable rates of preeclampsia, preterm rupture of membranes, fetal growth restriction, preterm birth, and neonatal unit admission [1]. A separate Spanish nationwide study found MCTD showed some of the strongest associations with preeclampsia and severe preeclampsia among the autoimmune diseases studied, suggesting it carries particularly elevated pregnancy-related risk compared to some other conditions in the same analysis [9].
- **Raynaud's phenomenon connection**: MCTD is mentioned as one of the autoimmune connective tissue diseases associated with secondary Raynaud's phenomenon, a condition involving exaggerated blood vessel spasms in the fingers, alongside conditions like systemic sclerosis and Sjögren's disease [4].
- **Lung involvement**: MCTD is noted as one of several systemic autoimmune rheumatic diseases that can contribute to interstitial lung disease (a condition affecting the lungs' tiss
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Joint painRaynaud's phenomenonSwollen fingersFatigueMuscle weaknessShortness of breath
Raynaud's phenomenon: a vascular or an autoimmune-mediated disorder? Facts and fancy.
Raynaud's phenomenon (RP) is a common vasospastic disorder characterized by transient digital ischemia triggered by cold exposure or emotional stress. It is classified as primary or secondary, the latter often associated with autoimmune connective tissue diseases such as systemic sclerosis, mixed co…
Phosphaturic Mesenchymal Tumour of the Soft Tissue in the Finger Presenting without Tumour-Induced Osteomalacia: A Case Report.
Phosphaturic mesenchymal tumour (PMT) is a rare neoplasm that can occur with or without tumour-induced osteomalacia (TIO). While PMTs commonly arise in the lower extremities or head and neck, digital involvement is rare. A 70-year-old man presented with a 12-year history of an enlarging subcutaneous…
Unmet needs in autoimmune liver disease: epidemiology and clinical outcomes from a Southeast Asian cohort.
The burden of autoimmune liver disease (AILD) is rising globally, yet data on its epidemiology and outcomes in Singapore remain limited. We aimed to characterise disease phenotype, treatment response and clinical outcomes among patients with autoimmune hepatitis (AIH), primary biliary cholangitis (P…
Impact of systemic autoimmune diseases in maternal, fetal and neonatal outcomes in Spain.
Pregnancy in autoimmune disease is increasingly feasible but carries heterogeneous maternal and perinatal risks beyond hypertensive disorders. We aimed to quantify disease-specific risks of maternal, fetal and neonatal outcomes across autoimmune diseases in a nationwide cohort, explicitly distinguis…
Interstitial lung disease in mixed connective tissue disease: Insights from an electronic health record-based retrospective cohort study.
Pulmonary complications, including interstitial lung disease (ILD), are common and contribute to morbidity and mortality in mixed connective tissue disease (MCTD). However, risk factors for ILD in MCTD are poorly understood, which can hinder early detection of this fatal complication. The purpose of…
Patient reports of evaluations for interstitial lung disease in patients with connective tissue diseases and rheumatoid arthritis: an international survey.
Connective tissue diseases (CTDs) and rheumatoid arthritis (RA) share the pulmonary complication of interstitial lung disease (ILD). However, real-world data on patient perspectives and experience regarding screening and evaluations for ILD following CTD/RA diagnosis are limited. We conducted an int…
[Analysis of the clinical characteristics of 45 cases of autoimmune liver disease in the Xizang population].
Objective: To explore the clinical, biochemical, immunological, and treatment characteristics of autoimmune liver disease in the Xizang population so as to provide a reference for clinical diagnosis and treatment in this region. Methods: Clinical data from 45 Xizang patients with autoimmune liver di…