Examining Cost Differences in Malignant Brain and Central Nervous System Tumor Treatment Across US Military Health System Care Settings.
The objectives of this study were to determine whether the cost of care for malignant brain and other central nervous system tumors (MBT) in the US Military Health System differs between the Department of War-operated direct care (DC) network and the affiliated civilian-operated private sector care…
Immune cell-derived membrane nanovesicles: A promethean fire for autoimmune disease therapy through immune cell mimicry.
Autoimmune diseases (AIDs) constitute a heterogeneous group of disorders characterized by immune dysregulation, loss of self-tolerance, and chronic inflammation, which leads to tissue damage and organ dysfunction. Current therapies for AIDs are often limited by their lack of specificity, systemic si…
Factors predicting health-enhancing physical activity in patients with chronic widespread pain following a person-centred health plan.
Regular physical activity improves symptoms and overall health in people with chronic widespread pain. However, many struggle to stay active over time, highlighting the need for strategies that support long-term physical activity. To investigate if person-centred health plans that include physical a…
Platycodin D attenuates proliferation, migration, and angiogenesis in RA-stimulated endothelial cells via CD146 modulation.
To investigate the effects of Platycodin D (PD) on the proliferation, migration, and angiogenesis of EA.hy926 endothelial cells stimulated by supernatant from a rheumatoid arthritis (RA) synovial cell model (MH7A), this study aims to preliminarily explore its potential mechanisms. The TNF-α-st…
Systematic identification of bacterial neuraminidase inhibitors from Psoralea corylifolia using ultrafiltration-UPLC-Q-Orbitrap-MS and molecular dynamics.
Bacterial neuraminidase (BNA) is a potential target for discovering anti-infective agents. Here, the BNA inhibitory activity of the ethanolic extract of Psoralea corylifolia (EEPC) was investigated using integrated experimental and computational approaches. Affinity ultrafiltration-UPLC-Q-Orbitrap-M…
Low-density granulocyte-driven NET formation is associated with poor prognosis in IgA nephropathy with thrombotic microangiopathy.
Thrombotic microangiopathy (TMA) is a common pathological phenotype of immunoglobulin A nephropathy (IgAN). Low-density granulocytes (LDGs) exhibit potent pro-inflammatory properties and promote neutrophil extracellular trap (NET) formation, playing a pivotal role in thrombus development. This study…
Tick-borne pathogens in dogs and their ticks in France: Molecular and serological evidence from a multicenter participatory study.
Canine tick-borne diseases (TBDs) are expanding globally, representing an increasing concern for both veterinary and public health. Dogs, due to their close contact with humans and frequent exposure to ticks, may serve as valuable sentinels for zoonotic risk. Between December 2022 and December 2023,…
Evaluation of long-term healthcare utilization and costs associated with COVID-19 among adults and children in the US.
This study assessed long-term healthcare resource utilization (HCRU) and direct medical costs associated with COVID-19 among adults and children in the United States. Using a large national claims database, we quantified the incremental healthcare burden during the year following a first COVID-19 di…