Hashimoto's is an autoimmune thyroid condition that leads to hypothyroidism, causing fatigue, weight gain, and cognitive impairment.
✦ AI summary
Here's what these sources cover on Hashimoto's Thyroiditis (HT):
**Genetics and mechanisms:** Research points to genes like CCDC77 and SLC45A3, which appear to influence HT through an inflammatory pathway involving interleukin-6 and NF-κB signaling; in mouse studies, altering these genes changed thyroid antibody levels and thyroid function [1]. More broadly, some autoimmune research suggests that changes to self-proteins in the body (not just genetics) may help explain why the immune system attacks the thyroid, a mechanism seen across several autoimmune diseases including thyroid disease [3].
**Diagnosis:** AI-assisted ultrasound analysis shows promising accuracy for identifying HT compared to standard ultrasound reading, though results vary depending on the population studied and how the AI model was built [12].
**Links to other conditions:**
- People with HT may have smaller thyroid tumors and less lymph node spread if they also have thyroid cancer, though HT itself doesn't seem to independently predict how aggressive a tumor behaves [11].
- HT overlaps with other thyroid conditions in surgical thyroid samples, including a rare fibr
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
FatigueWeight gainBrain fogDepressionCold intoleranceHair loss
CCDC77 and SLC45A3 mediate the genetic mechanism of Hashimoto's thyroiditis through IL-6.
Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder with a complex genetic background. Interleukin-6 (IL-6) has been implicated in its pathogenesis, but the genetic mechanisms remain unclear. Two-sample Mendelian randomization (MR) using expression quantitative trait loci (eQTL) and…
Causal effect of thyroid function on cortical brain structure: A two-sample Mendelian randomization study.
The causal relationship between variations in thyroid dysfunction and brain structure remains elusive. We intended to probe into this causal connection using a Mendelian randomization (MR) approach. Aggregated statistics from the genome-wide Association Study (GWAS) on Autoimmune thyroid dysfunction…
Long-term rheumatologic comorbidities in familial Mediterranean fever.
Familial Mediterranean fever (FMF) is characterized by pyrin inflammasome dysregulation and chronic subclinical inflammation. Whether FMF carries an increased long-term burden of rheumatologic and autoimmune inflammatory disease is unclear. We evaluated baseline and long-term occurrence of rheumatol…
Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity.
Autoimmune responses are often attributed to failed tolerance to self-proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk. This review presents a framework in which autoimmunity a…
Metabolic and hepatic differences among biochemically euthyroid individuals with distinct thyroid hormone sources: a comparative study.
This study aimed to evaluate the associations between thyroid hormone profiles and derived ratios (particularly the T3/T4 ratio), body composition parameters, and markers of hepatic steatosis and fibrosis in biochemically euthyroid individuals with distinct thyroid physiologies. Specifically, we sou…
Impact of autoimmune thyroiditis on IVF outcomes in patients with polycystic ovary syndrome and chronic endometritis.
To investigate the impact of autoimmune thyroiditis (AIT) on IVF/ICSI outcomes in patients with polycystic ovary syndrome (PCOS) and chronic endometritis (CE). This retrospective cohort study analyzed 444 oocyte retrieval cycles from patients with PCOS and CE who underwent IVF/ICSI treatment at Peki…
Emerging Links Between PFAS Exposure and Autoimmune Thyroid Disease: A Narrative Review of Epidemiologic Evidence, Mechanistic Insights, and Research Gaps.
Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely distributed in the environment and human tissues. Known as endocrine-disrupting chemicals, PFAS are increasingly investigated for their potential role in the rising global prevalence of autoimmune thyroid diseases (…
Clinical significance of coexisting Hashimoto's thyroiditis in differentiated thyroid cancer: a retrospective cohort study.
The association between Hashimoto's Thyroiditis (HT) and the clinicopathological behavior of Differentiated Thyroid Cancer (DTC) remains controversial. In particular, whether coexisting autoimmune thyroiditis independently influences invasive tumor characteristics after adjustment for tumor-related…