Peristomal Pyoderma Gangrenosum Related to Systemic Lupus Erythematosus: A Case Study.
Peristomal pyoderma gangrenosum (PPG) is a rare complication of peristomal skin. It is difficult to manage, and there are no guidelines for treatment. This case study describes the management of a patient with PPG while taking corticosteroids and cyclosporine as chronic therapy for systemic lupus er…
Immune cell-derived membrane nanovesicles: A promethean fire for autoimmune disease therapy through immune cell mimicry.
Autoimmune diseases (AIDs) constitute a heterogeneous group of disorders characterized by immune dysregulation, loss of self-tolerance, and chronic inflammation, which leads to tissue damage and organ dysfunction. Current therapies for AIDs are often limited by their lack of specificity, systemic si…
Multi-cohort transcriptomic analysis with machine learning identifies interferon-related candidate genes in systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with complex molecular mechanisms. Although transcriptomic studies have revealed prominent interferon signatures in SLE, robust prioritization of candidate genes across independent cohorts remains challenging. In this study, we…
Clinical predictors for bloodstream infection in systemic lupus erythematosus.
This study aimed to investigate the distribution of pathogenic bacteria and identify clinical predictors associated with bloodstream infection (BSI) in patients with systemic lupus erythematosus (SLE). The experimental group included 43 SLE patients with BSI (SLE-BSI), who were diagnosed and treated…
Poor sleep quality and its association patterns with eating disorders, body composition and physical activity among university students in Douala-Cameroon.
Poor sleep (PS) impacts university students' life including risk of eating disorders (EDs), changes in anthropometric parameters and body composition. However, physical activity (PA) protects against PS and its consequences. This study aimed to determine the prevalence of PS and its association patt…
SM03, a non-depleting anti-CD22 antibody, modulates B cell activation and immune crosstalk to attenuate autoimmunity.
To evaluate the disease-modifying potential of SM03, a novel humanized anti-CD22 monoclonal antibody, for B cell-mediated autoimmune diseases by investigating its mechanism for suppressing B cell dysregulation in autoimmune milieu. SM03's mechanism was assessed in-vitro using functional assays on st…
Sodium-relevant comorbidity risk factors are highly prevalent in individuals with narcolepsy or idiopathic hypersomnia.
Individuals with narcolepsy or idiopathic hypersomnia (IH) present with a high comorbidity burden that may confer elevated risk for negative clinical outcomes associated with excess sodium intake. This study characterized the prevalence and profiles of sodium-relevant comorbidity risk factors among…
WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
This study explored whether Lycium ruthenicum polysaccharide (LRP) influences gut microbiota-derived short-chain fatty acids (SCFAs) and neuroinflammatory responses in a sleep deprivation-induced CFS-like mouse model. Oral LRP was associated with improved fatigue-related behavioral performance, redu…