Non-suicidal self-injury and suicide attempts among individuals seeking assessment for Ehlers-Danlos Syndromes.
Individuals with Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobility Spectrum Disorder (G-HSD) experience psychological distress and are at an increased risk for suicidal behaviors. The current study examined associations between factors uniquely relevant to this population and prior suicide…
Meta-Analysis: Chronic Gastrointestinal Symptoms and Comorbidities in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders.
Patients with Ehlers-Danlos syndrome (EDS)/hypermobility spectrum disorders (HSD) report higher rates of chronic gastrointestinal (GI) symptoms, disorders of gut-brain interaction (DGBI), and extraintestinal comorbidities. We conducted a systematic review and meta-analysis to assess the prevalence o…
Obstructive sleep apnea and CPAP efficacy in patients with Hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder: a case-control study.
Hypermobile Ehlers-Danlos syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD) are hereditary tissue disorders existing on a spectrum associated with insomnia and obstructive sleep apnea (OSA). Oropharyngeal abnormalities in hEDS/HSD may exacerbate OSA; this study investigates if continuous pos…
Generalized Joint Hypermobility in Adolescent Idiopathic Scoliosis: Greater Curve Flexibility, Larger Thoracic Kyphosis, but Higher Complication Risk.
Generalized joint hypermobility (GJH) is prototypical clinical feature of hypermobility spectrum disorders, and emerging studies have found a correlation between GJH and structural spinal changes. This study aims to investigate the preoperative radiographic characteristics and clinical outcomes of p…
Differential thalamic GSH/Glu ratios Among primary headache subtypes and clinical implications: A cross-sectional magnetic resonance spectroscopy study.
BackgroundGlutathione (GSH) and glutamate (Glu) have been individually implicated in migraine pathophysiology, but their ratio as a marker of oxidative-excitatory balance in the thalamus-a key pain-processing hub-remains unexplored. This study investigated thalamic GSH/Glu ratios across primary head…
Too high and too loose: dysautonomia and the hypertensive paradox in hypermobility disorders.
Hypertension in hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) represents an increasingly recognized but poorly understood clinical phenomenon. This review addresses the unique pathophysiology, diagnostic considerations, and management challenges of hypertension…
Optimization of a Target Antigen Diagnostic Pathway for Membranous Nephropathy.
The recent Mayo Clinic consensus proposed a target antigen-based diagnostic pathway for membranous nephropathy (MN), recommending testing for neural epidermal growth factor-like 1 (NELL1) following a negative phospholipase A2 receptor (PLA2R) result. This study aimed to optimize this pathway in a re…
The hypermobility crisis: A review and call to action.
Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are common yet underrecognized connective tissue disorders characterized by joint hypermobility and multi-organ system involvement. Current diagnostic criteria inadequately capture the clinical heterogeneity of hEDS…