An inflammatory muscle disease causing progressive muscle weakness and inflammation.
✦ AI summary
Myositis is actually an umbrella term covering several different conditions, and the sources describe a range of subtypes and findings. Idiopathic inflammatory myopathies (IIM) include dermatomyositis, immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), and antisynthetase syndrome, each with distinct antibody patterns, muscle biopsy features, and clinical courses [3][5][7][9]. Some forms are linked to increased cancer risk, such as anti-TIF1γ-positive myositis, where about a quarter of patients had an associated tumor [6], while others, like anti-Jo-1 antisynthetase syndrome, can sometimes fully resolve with treatment and no cancer link [1]. Research also points to biological mechanisms, including mitochondrial dysfunction in IBM [4][11] and genetic risk variants shared with B-cell lymphomas [7]. Diagnosis often relies on muscle biopsy, and newer ultrasound-guided biopsy methods appear to work about as well as traditional open surgical biopsy but with fewer complications [8]. Myositis can also occur as a side effect of cancer immunotherapy (immune
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
A Rare Case of Four-year Complete Metabolic Response in Multisystem Anti-Jo-1 Antisynthetase Syndrome Assessed by 18 F-FDG PET/CT.
Antisynthetase syndrome (ASyS) is a rare idiopathic inflammatory myopathy with systemic manifestations, defined by the presence of anti-tRNA synthetase antibodies. Interstitial lung disease, particularly pulmonary fibrosis, is associated with a poorer prognosis. Here, we report a case of anti-Jo-1 p…
Proliferative myositis of the biceps brachii: A sarcoma mimicker.
Proliferative myositis is a rare benign intramuscular inflammatory pseudotumor that may clinically mimic a soft tissue sarcoma due to its rapid growth and painful presentation. We report the case of a 50-year-old man presenting with a rapidly enlarging, firm, and painful mass of the left arm, which…
Inflammatory myopathies with anti-TIF1γ antibodies and their association with neoplasms: a study of a series of 28 cases.
To describe the clinical, immunological, and evolutionary profile of patients with anti-TIF1γ-positive inflammatory myopathy and to analyze its association with neoplasms. Retrospective study of patients with inflammatory myopathy and positive anti-TIF1γ antibodies treated at a tertiary care hospita…
A Rare Association of Anti-SRP Antibody-Positive Immune-Mediated Necrotizing Myopathy and Sjögren Disease: Two Case Reports.
Immune-mediated necrotizing myopathy (IMNM) is an autoimmune myositis which is characterized by severe muscle fiber necrosis and refractoriness to immunotherapies. Overlap between myositis and other autoimmune disorders is well-recognized; however, the coexistence of IMNM and Sjögren disease (SjD) i…
Multilevel impairment of mitochondrial respiration in inclusion body myositis.
Oxidative phosphorylation (OXPHOS) is a central function and a key indicator of mitochondrial fitness, yet studies in human tissue remain limited. Inclusion body myositis (IBM) is a progressive myopathy that lies at the intersection of aging, inflammation and mitochondrial dysfunction. We aimed to p…
[Analysis of clinical and muscle pathological features of juvenile idiopathic inflammatory myopathy].
Objective: To investigate the clinical manifestations, muscle imaging features, and muscle pathological characteristics of juvenile idiopathic inflammatory myopathies (IIM). Methods: A retrospective cohort study was conducted including 76 children with IIM admitted to Children's Medical Center, Peki…
AAV.hBAG3 Gene Therapy Improves Phenotype in a Valosin Containing Protein Mouse Model of Hereditary Inclusion Body Myositis.
Mutations in the valosin-containing protein (VCP) gene lead to a hereditary type of inclusion body myositis (hIBM), in which sarcoplasmic and myonuclear inclusions with TAR DNA-binding protein 43 (TDP-43) pathology and mitochondrial abnormalities are observed in histological analysis. Pathophysiolog…
[Etiological investigation of inflammatory orbital disease in patients seen in internal medicine].
Inflammatory orbital diseases are characterized by inflammation that may involve any structure of the orbit including lacrimal gland, and may represent the manifestation of numerous disorders. Thereby, they are grouped under the term orbital inflammatory syndrome (OIS). A distinction is made between…