Quantitative Analysis of Placebo Response Models to Optimize Clinical Trials in Premenstrual Disorders: A Model-Based Meta-analysis.
This study quantitatively analyze the evaluation indicators used in premenstrual disorder clinical trials, establishes a placebo response model, observes its influencing factors, and provides a basis for the design of future clinical trials. A comprehensive search was conducted in PubMed, EMBASE, Co…
Clinical and genetic association of comorbid provisional PMDD and ADHD in female patients with bipolar disorder.
Premenstrual dysphoric disorder (PMDD) is a common comorbidity in bipolar disorder (BD), and its association with severe illness course and other comorbidity in BD has been reported. This study aims to investigate clinical characteristics and polygenic risk features of the subgroup with DSM-5-based…
Beyond general depression: Premenstrual interpersonal anger as a unique pathway to suicidal ideation in adolescent females with ADHD.
Adolescent females with ADHD exhibit heightened vulnerability to hormonal fluctuations, yet the specific clinical pathways associated with their acute suicide risk remain unclear. This study investigated whether ADHD diagnosis relates to premenstrual "Interpersonal Anger" and examined its sequential…
Prospective daily evidence of cyclic suicidality and self-harm in premenstrual disorders.
Suicide rates among reproductive-aged females have increased in recent decades, yet biopsychosocial contributors to risk remain understudied. Evidence suggests mood and behavior changes across the menstrual cycle, most notably in premenstrual disorders (PMDs), are associated with elevated suicide an…
Sleep in Women: The Current Status and Nuances in Management.
Sleep disturbances and disorders in women are influenced by hormonal, physiologic, and psychosocial factors across the reproductive lifecycle. Etiologies include menstrual cycle fluctuations, perimenopausal transitions, postmenopausal hormonal decline, and conditions such as premenstrual syndrome, p…
Evaluation and management of premenstrual dysphoric disorder.
Premenstrual dysphoric disorder (PMDD) is a condition that impacts the quality of life of those affected. Diagnosis can be difficult and lead to delays in treatment. In this article, we review current evidence for the evaluation and treatment of PMDD relevant to pediatric providers and their patient…
Prior reproductive and non-reproductive depression, and depressive symptoms in menopausal transition.
The menopausal transition is associated with an increased risk of depression. Prior depression is a well-established risk factor, but studies do not distinguish between prior reproductive and non-reproductive depression. We aimed to examine whether prior reproductive (i.e., premenstrual mood disorde…
Grey matter structural asymmetry and premenstrual dysphoric disorder.
Left-right brain asymmetry is an important feature of human neuroanatomy, with implications for cognition, behaviour, and vulnerability to mental disorders. Despite evidence for lateralized sensitivity to hormonal fluctuations, the cortical and subcortical asymmetry profile of individuals with preme…