Premenstrual Dysphoric Disorder causes severe emotional and physical symptoms in the luteal phase of the menstrual cycle.
✦ AI summary
Here's what this set of research sources says about PMDD (premenstrual dysphoric disorder):
- **Nature of the condition:** PMDD involves significant mood disturbances (like depression, anxiety, and irritability) plus physical symptoms that appear in the luteal phase before menstruation, and it's linked to dysregulation of hormones and neurotransmitters, with genetic, psychosocial, immune, and opioid-system factors playing a role [9]. Diagnosis is often difficult and delayed, and these challenges seem worse for people with other mental health conditions or marginalized identities [6].
- **Brain and body changes:** Studies using brain imaging have found differences in white matter and brain network connections in people with PMDD, especially in regions tied to emotion regulation and thinking [12]. Cognitive research suggests working memory and inhibitory control difficulties in PMS/PMDD appear to be persistent traits rather than only occurring during certain cycle phases [11]. Wearable heart-rate-variability tracking shows patterns that differ between those with and without PMDD around menstruation, suggesting potential for digital biomarkers [10].
- **Mental health links:** PMDD has been found to co-occur with bip
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Quantitative Analysis of Placebo Response Models to Optimize Clinical Trials in Premenstrual Disorders: A Model-Based Meta-analysis.
This study quantitatively analyze the evaluation indicators used in premenstrual disorder clinical trials, establishes a placebo response model, observes its influencing factors, and provides a basis for the design of future clinical trials. A comprehensive search was conducted in PubMed, EMBASE, Co…
Clinical and genetic association of comorbid provisional PMDD and ADHD in female patients with bipolar disorder.
Premenstrual dysphoric disorder (PMDD) is a common comorbidity in bipolar disorder (BD), and its association with severe illness course and other comorbidity in BD has been reported. This study aims to investigate clinical characteristics and polygenic risk features of the subgroup with DSM-5-based…
Prospective daily evidence of cyclic suicidality and self-harm in premenstrual disorders.
Suicide rates among reproductive-aged females have increased in recent decades, yet biopsychosocial contributors to risk remain understudied. Evidence suggests mood and behavior changes across the menstrual cycle, most notably in premenstrual disorders (PMDs), are associated with elevated suicide an…
Sleep in Women: The Current Status and Nuances in Management.
Sleep disturbances and disorders in women are influenced by hormonal, physiologic, and psychosocial factors across the reproductive lifecycle. Etiologies include menstrual cycle fluctuations, perimenopausal transitions, postmenopausal hormonal decline, and conditions such as premenstrual syndrome, p…
Evaluation and management of premenstrual dysphoric disorder.
Premenstrual dysphoric disorder (PMDD) is a condition that impacts the quality of life of those affected. Diagnosis can be difficult and lead to delays in treatment. In this article, we review current evidence for the evaluation and treatment of PMDD relevant to pediatric providers and their patient…
Design, synthesis, and quantitative structure-activity modeling of indole-3-pyrimidine hydrazone derivatives as novel antifungal agents.
Fungicides remain the primary approach for preventing and controlling agricultural and forestry fungal diseases. However, the inevitable emergence of antifungal drug resistance in plant pathogenic fungi necessitates novel multi-target fungicides. A series of novel indole-3-pyrimidine hydrazones were…
Prevalence, Risk Factors, and Treatments for Suicidality in People Living with Premenstrual Dysphoric Disorder (PMDD): A Systematic Review.
In 2013, premenstrual dysphoric disorder (PMDD) was officially recognized as a psychiatric diagnosis. It is estimated to affect 1.3% to 5.8% of people who menstruate. Previous evidence has suggested an association between PMDD and suicidality. We set out to systematically review the most up-to-date…
Association of premenstrual syndrome and premenstrual dysphoric disorder with suicidal ideation and violence toward family members in Japan.
To examine association of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) with suicidal ideation and violence toward family members among Japanese women of reproductive age. We analyzed data from the 2023 Japan COVID-19 and Society Internet Survey (JACSIS), a nationwide online…