Vulvodynia

123 papers & discussions

Chronic vulvar pain without an identifiable cause, significantly affecting quality of life.

✦ AI summary

Vulvodynia is chronic vulvar pain lasting at least three months without a clear cause, affecting an estimated 10–16% of women, and it's considered a "chronic overlapping pain condition" that often occurs alongside things like fibromyalgia, IBS, and interstitial cystitis [11][12]. Research points to several possible contributors: nerve-related changes (like extra nerve endings and overactive pain receptors in the vulvar area), immune system dysfunction, hormone influences, and shifts in the vaginal/gut microbiome [3][8][11]. People diagnosed with vulvodynia have also been found to have higher later rates of infections, mental health diagnoses, other genital tract issues, and skin conditions compared with those without it, suggesting broader body-wide effects rather than just localized pain [10]. On the treatment side, studies have looked at approaches such as a topical nerve-desensitizing cream (resiniferatoxin), which showed pain reduction in a small trial [3], and acupuncture, which one trial suggested could have lasting benefits for some responders, though this generated scientific debate [4][9]. Researchers also use tools like the "tampon test" to measure insertional pain in clinical trials, though

This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.

Burning painStingingRawnessPainful intercourseItchingPelvic floor tension

Research

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PubMed

Tampon test measurement properties in women with provoked vestibulodynia: baseline data from a pragmatic randomized clinical trial.

Provoked vestibulodynia (PVD) is a common cause of dyspareunia in young women. Because intercourse-related pain cannot be assessed consistently in all affected women, the tampon test (TT) is often used as a standardized proxy for insertional pain. This study aimed to evaluate within-person variabili…

vulvodynia
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PubMed

Preclinical models of female pelvic pain disorders.

Pain is influenced by a complex interplay of biological, psychological, and social factors. Sex has emerged as a key determinant of vulnerability to chronic pain and a major risk factor for poor response to available pharmacological treatments. Women report higher rates of chronic pain and exhibit g…

chronic painendometriosisadenomyosisinterstitial cystitis
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PubMed

Topical resiniferatoxin for the treatment of vestibulodynia: a prospective observational trial.

Vestibulodynia is the most common subtype of vulvodynia and is characterized by persitent, contact-evoked pain localized to the vulvar vestibule. Increasing evidence supports a neuropathic pain mechanism in vestibulodynia, including vestibular hyperinnervation, neuroinflammation, and overexpression…

vulvodynia
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PubMed

Molecular mechanisms and therapeutic perspectives in vulvodynia: From current evidence to future investigations.

Vulvodynia is defined as chronic vulvar pain persisting for at least 3 months without a clear identifiable cause. It affects 10%-16% of women, and despite its high prevalence and the severity of symptoms, vulvodynia remains significantly understudied. Here, we consolidate and analyze the scientific…

vulvodynia
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PubMed

Bilateral adrenalectomy as a cause of vulvar pain and dyspareunia.

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PubMed

The Association Between Vulvodynia and Subsequent Morbidity Across the Life Course.

Vulvodynia is chronic vulvar pain frequently associated with other comorbid chronic pain conditions. However, it is unclear whether women with vulvodynia experience higher rates of non-pain-related disorders after first onset of vulvar pain relative to unexposed women. Women born in Sweden between 1…

chronic painvulvodynia
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PubMed

Response to the comment on "Long-lasting effect of penetrating acupuncture among responders: Double-blind RCT of acupuncture for vulvodynia".

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PubMed

Comment on "Long-lasting effect of penetrating acupuncture among responders: Double-blind RCT of acupuncture for vulvodynia".

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