Thyroid eye disease with teprotumumab-related hyperglycemia associated with increased growth hormone secretion.
Teprotumumab, an insulin-like growth factor-1 (IGF-1) receptor antibody, has been approved for thyroid eye disease (TED) treatment. However, teprotumumab is associated with adverse events such as hyperglycemia, and the underlying mechanisms of teprotumumab-related hyperglycemia remain unclear. We re…
Clinical outcomes of thyroid function in patients with thyrotropin receptor blocking antibody-positive hypothyroidism.
Thyrotropin receptor blocking antibodies (TBAbs) are uncommon but not a rare cause of hypothyroidism. However, clinical outcomes of thyroid function in patients with TBAb-positive hypothyroidism remain unclear. The aim of this study was to explore the clinical outcomes of thyroid function in patient…
Upregulated differentially expressed genes in thyroid eye disease after indirect exclusion of GD signals.
BackgroundThyroid eye disease (TED) is a vision-threatening autoimmune disorder, and the molecular mechanisms underlying thyroid eye disease (TED), particularly those independent of typical Graves' Disease (GD) signals, remain unclear.ObjectiveThis study aimed to identify upregulated differentially…
Pharmacogenomic screening strategy and indicative screening efficiency for antithyroid drug-induced agranulocytosis in the Southern Han Chinese.
Antithyroid drug-induced agranulocytosis (ATDIA) is a life-threatening adverse drug reaction with strong population-specific genetic predispositions. This study aimed to develop a pharmacogenomic risk-stratification model and to evaluate the indicative screening efficiency of targeted pretherapeutic…
TSH receptor autoantibodies - a personal experience.
Nineteen fifty six was a pivotal year in our understanding of thyroid disease with the discovery of long acting thyroid stimulator (LATS) in the serum of patients with Graves' disease and autoantibodies to thyroglobulin in Hashimoto's disease. Soon after its discovery, LATS was shown to be a thyroid…
Management of Graves' Disease in Chinese Children and adolescents: A survey of current clinical practice.
To investigate the current status of treatment, monitoring strategies, and variations in clinical decision-making for childhood Graves' disease (GD) among Chinese children. A self-designed questionnaire was distributed via an online platform to physicians from the Endocrine Genetic Metabolism Group…
New-onset Systemic Lupus Erythematosus after Methimazole Exposure Followed by Autoantibody Emergence.
Methimazole-associated new-onset systemic lupus erythematosus (SLE) is rare and it may be difficult to distinguish from classic drug-induced lupus. We report a 19-year-old man who developed fever, polyarthralgia, rash, and ocular pain three months after initiating methimazole for Graves' disease. At…
Association between long-term exposure to environmental coarse particulate matter and the prevalence of thyroid disorders: a cross-sectional study in China.
Evidence linking long-term exposure to particulate matter with thyroid dysfunction is increasing, but data on particulate matter 10 micrometers or less (PM10) exposure and thyroid disorders remain limited. 73,900 subjects aged ≥ 18 years from a nationwide population-based study were included.…