Persistent fatigue lasting six months or more that is not relieved by rest and limits daily activity.
✦ AI summary
Chronic fatigue shows up in these sources both as a standalone condition (myalgic encephalomyelitis/chronic fatigue syndrome, ME/CFS) and as a common symptom alongside other illnesses. People with ME/CFS report a heavy day-to-day burden — worse quality of life, physical and mental functioning than people without the condition, with symptoms varying enough that researchers are trying to identify distinct subgroups [7]. Research is exploring many possible biological pieces: gut microbiota and short-chain fatty acids, immune and neuroinflammatory changes, autonomic nervous system function, and blood markers like extracellular vesicle proteins, though findings are still preliminary or exploratory [1][2][3]. Some studies also look at practical/environmental factors, like how light exposure patterns relate to fatigue, sleep, and quality of life [10], and note that ME/CFS patients undergoing surgery had lower blood pressure/heart rate readings and more reported pain, though the study was small [11]. On treatment, larger trials testing immune-targeted therapies (like plasma exchange or antibody-based drugs) didn't show benefit in general ME/CFS populations, suggesting any benefit may
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Severe fatiguePost-exertional worseningSleep problemsBrain fogPainMood disturbance
Multimodal approach to identify neuropsychophysiological subgroups in myalgic encephalomyelitis/chronic fatigue syndrome and their relevance for rehabilitation: protocol for a mechanistic cross-sectional and longitudinal study.
Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is a debilitating condition characterized by severe fatigue and post-exertional malaise (PEM). Reported neuropsychophysiological abnormalities suggest ME/CFS is multifactorial, but current knowledge remains fragmented. This study protocol…
Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying biological cargo a…
WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
This study explored whether Lycium ruthenicum polysaccharide (LRP) influences gut microbiota-derived short-chain fatty acids (SCFAs) and neuroinflammatory responses in a sleep deprivation-induced CFS-like mouse model. Oral LRP was associated with improved fatigue-related behavioral performance, redu…
me cfslupuschronic fatiguerelapsing polychondritis
Psychological Aspects of Rheumatic Diseases: Psychorheumatology in Clinical Practice.
Rheumatic diseases (RDs) significantly impact patients' physical, psychological, and social well-being, yet psychological dimensions remain inadequately addressed in routine clinical practice. In this commentary, we examine psychological manifestations and mental health comorbidities in RDs, such as…
Therapeutic plasma exchange and immunomodulatory strategies in post-infectious syndromes: A review of immune dysregulation in PTLDS, long COVID, ME/CFS, and PANS/PANDAS.
Post-infectious syndromes including post-treatment Lyme disease syndrome (PTLDS), long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and pediatric acute-onset neuropsychiatric syndrome (PANS)/pediatric autoimmune neuropsychiatric disorders associated with streptococcal infectio…
Evaluation of an Invisible Illness Communication Strategy Curriculum Among Internal Medicine Interns.
Patient-physician communication in invisible illness is challenging. Invisible illnesses (e.g., fibromyalgia, myalgic encephalomyelitis/chronic fatigue syndrome, and disorders of gut-brain interaction) are clinical syndromes that are not readily visible or measurable by physical exam or diagnostic t…
What is the Role of "the Psyche"? Long COVID and ME/CFS as Test Cases for Evidence-Based and Patient-Centered Psychiatry and Psychotherapy.
The role of psychological factors in the development and course of Long Covid (LC) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) remains a subject of controversial debate. We argue that psychologizing LC and ME/CFS carries significant risks: it leads to potentially harmful therapie…
The Role of Psychological Flexibility in Health-Related Quality of Life Among Patients With Persistent Physical Symptoms Associated With Indoor Environment and Chronic Fatigue - 9-Month Follow-Up of a Randomized Controlled Trial.
Persistent physical symptoms (PPS) can significantly impair health-related quality of life (HRQoL). Psychological flexibility (PF), characterized by the ability to adapt functionally and congruently to diverse situations based on personal values, may moderate the impairment of HRQoL. This study exam…