A disease causing clusters of inflammatory cells (granulomas) to grow in the lungs, lymph nodes, and other organs.
✦ AI summary
Sarcoidosis is a condition where the immune system forms small clusters of inflammatory cells called granulomas, most often in the lungs and nearby lymph nodes, though the exact cause remains unclear [11]. Research points to a mix of environmental exposures (like certain airborne particles) combined with genetic factors as likely contributors, though the specifics are still being worked out [7]. It can show up in surprising places beyond the lungs, including bones, skin, the nervous system, and the heart, sometimes mimicking other serious diseases like cancer or infections, which can make diagnosis tricky [1][2][3][9]. For the heart specifically, researchers are refining imaging tools to better predict who is at risk for serious complications like abnormal heart rhythms [8][12]. On the treatment side, corticosteroids (like prednisone) have long been the standard therapy, but newer clinical trial evidence suggests lower doses may work just as well as higher ones, and other medications such as methotrexate can be effective alternatives, especially since long-term steroid use is linked to significant side effects [11][5]. For more severe or advanced lung disease, doctors are increasingly using imaging and lung function tests to monitor progression and are shifting toward
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Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.
Granulomas can be found in different tissues and are associated with a variety of processes. To understand the primary diagnoses is the aim of this study. We retrospectively described a cohort of patients with a diagnosis of granulomas in histopathological samples over an 11-year period. Demographic…
Tumefactive parenchymal lesion of neurosarcoidosis responsive to infliximab.
Neurosarcoidosis is an uncommon manifestation of systemic sarcoidosis and can involve any part of the nervous system. Intraparenchymal tumefactive lesions are particularly rare and pose a diagnostic challenge due to their radiographic resemblance to high-grade gliomas or metastatic disease. Optimal…
Unveiling the unexpected: Skeletal sarcoidosis with an extraosseous soft-tissue mass in the ligamentous portion of sacroiliac joint.
Sarcoidosis is a chronic granulomatous, multisystem disease of uncertain etiology that affects various organ systems, although musculoskeletal involvement is rarely the dominant feature. We present the case of a woman in her 50s with a history of pulmonary sarcoidosis who developed new lower back an…
Pragmatic approaches to improve the care of patients with sarcoidosis.
Sarcoidosis is associated with an increasing global burden, driven by rising prevalence, severe organ involvement, treatment-related morbidity, and substantial impairment in quality of life (QoL). Despite advances in diagnostics and therapeutics, important barriers continue to limit timely, equitabl…
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This review describes recent developments in the phenotyping, monitoring, and treatment of advanced pulmonary sarcoidosis (APS), highlighting the positive strides made to recognise and treat this severe form of disease. Key to this is the use of recently described high-resolution chest computed tomo…
This review addresses the intersection between chronic pulmonary aspergillosis (CPA) and sarcoidosis, a clinically important but relatively understudied association. While few new sarcoidosis-specific data have emerged, recent advances in CPA research across broader underlying conditions (particular…
Current understanding of environmental exposures and sarcoidosis.
Sarcoidosis is a heterogeneous disease with unknown etiology. The role of exposures in sarcoidosis is incompletely understood. Gene-environment interactions are likely an important aspect of sarcoidosis etiology and phenotypes. This review critically evaluates the current literature regarding the ro…
Strict carbohydrate restriction enables volume-based FDG-PET/CT to outperform SUVmax for risk stratification in cardiac sarcoidosis.
FDG-PET/CT SUVmax reflects focal metabolic intensity but not the patchy inflammatory burden of cardiac sarcoidosis (CS). We evaluated whether volume-based total cardiac metabolic volume (tCMV) and total cardiac metabolic activity (tCMA), measured after optimized suppression, predict long-term major…