Granulomatous inflammation in histopathological samples: examining the aetiological spectrum, diagnostic challenges, and future perspectives.
Granulomas can be found in different tissues and are associated with a variety of processes. To understand the primary diagnoses is the aim of this study. We retrospectively described a cohort of patients with a diagnosis of granulomas in histopathological samples over an 11-year period. Demographic…
Tumefactive parenchymal lesion of neurosarcoidosis responsive to infliximab.
Neurosarcoidosis is an uncommon manifestation of systemic sarcoidosis and can involve any part of the nervous system. Intraparenchymal tumefactive lesions are particularly rare and pose a diagnostic challenge due to their radiographic resemblance to high-grade gliomas or metastatic disease. Optimal…
Unveiling the unexpected: Skeletal sarcoidosis with an extraosseous soft-tissue mass in the ligamentous portion of sacroiliac joint.
Sarcoidosis is a chronic granulomatous, multisystem disease of uncertain etiology that affects various organ systems, although musculoskeletal involvement is rarely the dominant feature. We present the case of a woman in her 50s with a history of pulmonary sarcoidosis who developed new lower back an…
Pragmatic approaches to improve the care of patients with sarcoidosis.
Sarcoidosis is associated with an increasing global burden, driven by rising prevalence, severe organ involvement, treatment-related morbidity, and substantial impairment in quality of life (QoL). Despite advances in diagnostics and therapeutics, important barriers continue to limit timely, equitabl…
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This review describes recent developments in the phenotyping, monitoring, and treatment of advanced pulmonary sarcoidosis (APS), highlighting the positive strides made to recognise and treat this severe form of disease. Key to this is the use of recently described high-resolution chest computed tomo…
This review addresses the intersection between chronic pulmonary aspergillosis (CPA) and sarcoidosis, a clinically important but relatively understudied association. While few new sarcoidosis-specific data have emerged, recent advances in CPA research across broader underlying conditions (particular…
Current understanding of environmental exposures and sarcoidosis.
Sarcoidosis is a heterogeneous disease with unknown etiology. The role of exposures in sarcoidosis is incompletely understood. Gene-environment interactions are likely an important aspect of sarcoidosis etiology and phenotypes. This review critically evaluates the current literature regarding the ro…
A systematic review of abatacept and belatacept in immune-mediated diseases.
Abatacept (ABA) and belatacept (BEL) are immunomodulatory fusion proteins in which the extracellular domain of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is linked to the Fc fragment of human IgG1. Functionally, they bind to cell surface antigens CD80 and CD86 on antigen-presenting cells,…