Type III interferons attenuates Th1/Th17 cell pathogenicity and regulates retinal pigment epithelium cells via NLRP1/NLRP3 signaling axis in autoimmune uveitis.
Accumulating data implicate Type III interferons (IFN-λs) in autoimmune disorders, prompting our exploration of their role in uveitis pathogenesis. Serum and peripheral blood mononuclear cells (PBMCs) from patients with active Vogt-Koyanagi-Harada (VKH) and active Behçet's disease (BD) we…
Assessment of long-term organ damage and predictors of damage accrual in Behçet's syndrome: a 10-year longitudinal study using the Behçet's Syndrome Overall Damage Index.
To assess long-term organ damage and its accrual in a real-life cohort of Behçet's syndrome (BS) patients using the Behçet's Syndrome Overall Damage Index (BODI), identifying predictors of damage at diagnosis and factors associated with its accrual during follow-up. This single-centre retr…
Ustekinumab for Intestinal Behçet's Disease: The First Cohort with a Novel Therapy.
Evidence-based treatments for intestinal Behçet's disease (BD) remain limited. There is an unmet need for the development of effective therapies for refractory cases. We aimed to evaluate the safety and efficacy of ustekinumab, an anti-interleukin (IL)-12/23 monoclonal antibody, for intestinal…
Clinical and diagnostic characteristics of arterial involvement in paediatric Behçet's disease.
To explore the clinical features, diagnosis, treatment and prognosis of arterial involvement in paediatric Behçet's disease (BD) for clinical reference. A retrospective cohort study analysed 76 paediatric BD patients (January 2013 - May 2024). Nineteen with arterial involvement were the experim…
Tree-based machine learning models recover rule-based flare labels from virtual symptom diaries in pediatric Behçet's disease: an in silico proof-of-concept study.
Behçet's disease (BD) in childhood is characterised by recurrent inflammatory flares that can result in significant morbidity, most notably with ocular, mucocutaneous, and musculoskeletal manifestations. Timely detection of impending flares is difficult in routine practice, and digital health t…
Diagnosis, treatment and monitoring of pediatric Behçet's disease: Systematic literature review informing the ISSAID/PRES recommendations.
Pediatric-onset Behçet's disease (BD) accounts for up to 20% of cases and represents a distinct clinical entity characterized by evolving phenotypes and age-specific patterns of organ involvement. This systematic literature review synthesizes current evidence on pediatric BD, informing forthcom…
The epidemiology of Behçet's disease in Brazil: a study in Goiânia and its metropolitan area.
The goal of this study is to evaluate the epidemiology of Behçet's disease (BD) in the city of Goiania and its metropolitan area. This epidemiological study had a cross-sectional design. Patients who had a diagnosis of BD living in the metropolitan area of Goiânia and with at least one med…
Efficacy and safety of Janus kinase inhibitors in Behçet's disease: A systematic literature review.
Behçet's disease e (BD) is a chronic, relapsing, multisystem inflammatory disorder that if not successfully treated can lead to severe, organ or life-threatening complications. Despite treatment with glucocorticoids, immunosuppressants, and tumor necrosis factor (TNF) inhibitors, some patients…