An autoimmune disorder causing abnormal clotting and pregnancy complications due to antiphospholipid antibodies.
✦ AI summary
Here's what these sources report about Antiphospholipid Syndrome (APS):
Research shows that APS involves antibodies (like lupus anticoagulant and anticardiolipin) that raise the risk of blood clotting problems. Even outside a formal APS diagnosis, people who test positive for these antibodies while hospitalized had higher rates of death and hospital readmission over a 10-year study, particularly those with lupus anticoagulant or certain antibody types [5]. In its most severe form, called catastrophic APS (CAPS), skin problems are common, affecting almost half of episodes in a large patient registry — most often a mottled skin pattern (livedo reticularis) and skin tissue death; this form of APS also frequently affects the kidneys, lungs, brain, and heart, though having skin involvement itself didn't appear to change survival odds [3]. In lupus patients, APS-related antibodies can also contribute to a kidney complication called thrombotic microangiopathy, identified as one of the main disease patterns in a large cohort study [8]. For pregnancy, lab research suggests that APS antibodies may disrupt placental cells in ways that could contribute to recurrent miscarriage, through changes in tiny cell
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
This review describes recent developments in the phenotyping, monitoring, and treatment of advanced pulmonary sarcoidosis (APS), highlighting the positive strides made to recognise and treat this severe form of disease. Key to this is the use of recently described high-resolution chest computed tomo…
EVT-Derived Migrasomes Provide Mechanistic Insights Into Antiphospholipid Syndrome-Associated Recurrent Miscarriage.
Recurrent miscarriage (RM) is a complex pregnancy-related disorder closely associated with impaired extravillous trophoblast (EVT). Antiphospholipid antibody syndrome (APS) is an autoimmune condition that contributes to adverse pregnancy outcomes, including RM. However, the mechanism by which APS in…
Photopolymerizable placenta-derived ECM hydrogel enhances hUC-MSC-mediated wound healing via coordinated immunomodulation and angiogenesis.
Mesenchymal stromal/stem cells (MSCs) hold great promise for regenerative medicine due to their potent immunomodulatory properties and favorable safety profile. However, their low survival, poor retention, and limited engraftment in injured tissues remain major barriers to clinical efficacy. Here, w…
Antiphospholipid antibodies among hospitalized patients predict mortality and readmission: A real-world 10-years cohort study.
Antiphospholipid antibodies (aPL) are markers of increased morbidity and mortality in patients with antiphospholipid syndrome. However, the prognostic significance of aPL positivity in hospitalized patients without antiphospholipid syndrome remains unclear. This real-world study evaluated the indepe…
Mild Thyroid Eye Disease-The Most Common yet the Least Studied Presentation of Thyroid Eye Disease.
Mild thyroid eye disease (TED) is the most common form of TED, yet it is the least studied. Uncertainties about the natural history and prevention, and underfunding for clinical research, are an obstacle to improving the management of this important group of patients. The available evidence suggests…
Perioperative Use of Efgartigimod Alfa, a Neonatal Fc Receptor Antagonist, to Reduce Antiphospholipid Antibody Titers and Thrombotic Risk in a Kidney Transplant Recipient.
Antiphospholipid syndrome (APS) is associated with an increased risk of thrombotic complications after kidney transplantation, particularly in patients with persistently elevated and triple-positive antiphospholipid antibodies (aPLs). Management of APS in kidney transplantation relies primarily on p…
Skin involvement in the catastrophic antiphospholipid syndrome: A review from CAPS registry.
ObjectiveTo describe the prevalence, clinical manifestations, histopathological features, and antibody profile associated to skin involvement in patients with catastrophic antiphospholipid syndrome (CAPS).MethodsWe performed a cross-sectional study of the patients included in the "CAPS Registry," a…
Clinical phenotypes and etiologic subtypes of thrombotic microangiopathy in systemic lupus erythematosus.
Thrombotic microangiopathy (TMA) is a rare and severe complication of systemic lupus erythematosus (SLE). While classically defined by microangiopathic hemolytic anemia, thrombocytopenia, and organ damage, TMA may also present as a renal-limited process requiring histologic diagnosis. Data character…