Prognostic impact of multi-divisional trigeminal neuralgia on pain outcomes following microvascular decompression.
Microvascular decompression (MVD) is the gold standard surgical treatment for medically refractory trigeminal neuralgia (TN). Pain distribution in TN is heterogeneous, with multi-divisional involvement representing a substantial patient subset; however, whether division pattern predicts MVD outcomes…
Percutaneous balloon compression followed by perineural methylprednisolone for trigeminal neuralgia: A 50-patient retrospective series with 12-month outcomes.
To describe pain outcomes and safety after a combined protocol of percutaneous balloon compression (PBC) followed immediately by perineural methylprednisolone in adults with pharmacoresistant trigeminal neuralgia. We conducted a multicentre, single-arm, retrospective observational series without a c…
Painful tic convulsif: Dual neurovascular compression within the spectrum of cranial nerve hyperactive dysfunction syndromes.
Concurrent trigeminal neuralgia (TN) and hemifacial spasm (HFS), historically termed painful tic convulsif, is a rare manifestation of cranial nerve hyperactive dysfunction associated with neurovascular compression. The operative anatomy may involve independent conflicts affecting cranial nerves V a…
Pearls & Oy-sters: Bilateral Neuropathic Facial Pain With Autonomic Features and Neurovascular Contact.
Trigeminal neuralgia (TN) is an uncommon disorder, with an annual prevalence of 0.03%-0.3% in North America. It is typically unilateral, most commonly involving the V2 and V3 distributions and may be accompanied by mild autonomic features. We report a 35-year-old woman who developed severe right mor…
ROS-responsive nanoplatform-mediated targeted intranasal delivery of Piezo2 siRNA for the treatment of trigeminal neuralgia.
Trigeminal neuralgia (TN) is one of the most severe neuropathic pain conditions, yet current pharmacological treatments are hindered by low bioavailability, systemic toxicity, and drug resistance. The mechanosensitive ion channel Piezo2 has been identified as a key mediator of orofacial mechanical a…
Trigeminal motor root anatomy from pons to foramen ovale and its surgical implications: A study using epoxy sheet plastination and three-dimensional reconstruction.
Surgical treatments for trigeminal neuralgia are frequently limited by postoperative pain recurrence and unexpected sensory preservation, while the detailed microanatomy of the trigeminal motor root and its anatomical variants remain incompletely understood. To address this gap, we conducted a detai…
Esketamine alleviates trigeminal neuralgia and anxiety-like behaviors in mice by inhibiting RIPK1/RIPK3/MLKL-mediated necroptosis.
Trigeminal neuralgia (TN) is a debilitating orofacial pain condition frequently complicated by anxiety and depression, forming a self-reinforcing pain-affect cycle with limited therapeutic options. A TN mouse model with anxiety-like behavior was established using partial infraorbital nerve transecti…
Botulinum Toxin Type A for Trigeminal and Postherpetic Neuralgia: An Umbrella Review of Systematic Reviews.
BACKGROUND AND OBJECTIVE: Trigeminal neuralgia (TN) and postherpetic neuralgia (PHN) are severe peripheral neuropathic pain conditions associated with substantial functional impairment. Although pharmacological treatments are available, many patients experience insufficient efficacy or poor tolerabi…