Dysautonomia is an umbrella term for disorders of the autonomic nervous system that regulate involuntary body functions.
✦ AI summary
Dysautonomia (autonomic nervous system dysfunction) shows up across many conditions and affects people in varied ways. In POTS specifically, hives and mast cell activation are common and linked to greater overall symptom burden, including gut, bladder, and pain-related symptoms [1]. Long-term studies show POTS symptoms often persist for decades, though many people report gradual improvement over time, especially those without additional issues like neuropathy or gastroparesis [4]. Dysautonomia also appears alongside other conditions—such as Long COVID (where it's tied to brain blood flow changes and inflammation) [5], Sjögren's disease (as part of a broader quality-of-life impact) [6], sarcoidosis (contributing to fatigue and reduced function) [3], and pediatric IBD/IBS (linked to gut motility changes) [9]. In children, autonomic dysfunction frequently co-occurs with mental health conditions like anxiety, though the reported order of onset varies from person to person [12]. Overall, research suggests dysautonomia is a multisystem, individualized experience rather than a single uniform condition, often requiring broader symptom tracking beyond standard heart-rate or blood-pressure tests
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Orthostatic intoleranceHeart palpitationsTemperature dysregulationFatigueGI issuesBrain fog
Hives in autonomic disorders: a cutaneous marker of a distinct symptom phenotype.
Postural Orthostatic Tachycardia Syndrome (POTS) and Neurally-Mediated Hypotension (NMH) are heterogeneous syndromes characterized by dysautonomia and multisystem symptoms. Mast cell activation, often manifesting as hives, has been proposed as a contributing mechanism, but its prevalence and clinica…
Wilkie syndrome combined with nutcracker syndrome presented as syncopal episodes: A case report.
Combined aortomesenteric compression is an extremely rare vascular condition where both the duodenum (Wilkie) and the left renal vein (nutcracker) are compressed between the aorta and the superior mesenteric artery (SMA). The causal factor is the abnormal course of the SMA originating from the abdom…
Pragmatic approaches to improve the care of patients with sarcoidosis.
Sarcoidosis is associated with an increasing global burden, driven by rising prevalence, severe organ involvement, treatment-related morbidity, and substantial impairment in quality of life (QoL). Despite advances in diagnostics and therapeutics, important barriers continue to limit timely, equitabl…
dysautonomiasarcoidosissmall fiber neuropathybrain fog
Long-term outcomes in patients with postural orthostatic tachycardia syndrome with an average follow-up of over 20 years.
Postural orthostatic tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance that primarily affects female patients. There are scarce data evaluating the long-term outcomes in POTS. This study sought to evaluate the long-term impacts of POTS over multiple decades in adult patients.…
Central sensitization in long COVID: Associations with autonomic symptom burden, cerebral hypoperfusion, and neuroinflammation.
The mechanisms driving the broad spectrum of Long COVID symptoms-such as fatigue, brain fog, pain, and dysautonomia-remain uncertain. This study investigated central sensitization (CS) as a potential contributor to symptom burden in patients with Long COVID. We aimed to examine its association with…
Non-suicidal self-injury and suicide attempts among individuals seeking assessment for Ehlers-Danlos Syndromes.
Individuals with Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobility Spectrum Disorder (G-HSD) experience psychological distress and are at an increased risk for suicidal behaviors. The current study examined associations between factors uniquely relevant to this population and prior suicide…
Autonomic nervous system influences on beat-to-beat blood pressure variability in healthy young adults.
Based on evidence from 24-h and visit-to-visit blood pressure (BP) monitoring, recent laboratory-based studies have begun investigating beat-to-beat average real variability (ARV) in BP as a prognostic indicator of cardiovascular risk. However, beat-to-beat BP ARV may be influenced by adaptive paras…
Fractionated Atrial Electrograms Identify Sites of Autonomic Responses During Pulmonary Vein Isolation: Insights for Cardioneuroablation.
Cardioneuroablation (CNA) targets atrial ganglionated plexuses (GP) to treat vagally mediated bradyarrhythmias. Automated electrogram fractionation mapping has been proposed as a surrogate tool for GP localization, but optimal parameter settings remain undefined. We aimed to systematically evaluate…