Inflammation of blood vessels that can damage organs and restrict blood flow throughout the body.
✦ AI summary
Research on vasculitis covers many different angles. Sleep problems are very common—one large survey found about 82% of vasculitis patients reported sleep disturbances, with sleep apnea more common in men and insomnia/daytime sleepiness more common in women, linked to factors like pain, weight, smoking, and kidney involvement rather than the specific vasculitis subtype [1]. People with vasculitis and related rheumatic diseases also report high rates of depression, anxiety, fatigue, and reduced quality of life, which has led to calls for combining mental health support with rheumatology care [7].
On the disease itself, ANCA-associated vasculitis (a group including GPA, MPA, and EGPA) is now understood as a complex immune disorder involving antibodies, complement activation, and neutrophils, and treatment has moved from older drugs toward more targeted therapies like rituximab, avacopan, and newer experimental options [3]. Specific research has looked at complement-related proteins linked to more severe kidney damage [8], models to predict relapse or steroid-dependence in EGPA [4], vasculitis triggered by cocaine/levamisole exposure that mimics GPA but has distinct features [6], and even vasculitis
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Research on sleep patterns in individuals with vasculitis remains limited. This SleepVasc study aimed to 1) evaluate sleep disturbances and a range of sleep health dimensions in individuals with vasculitis, and 2) identify potential risk factors for sleep problems/disturbances/disorders. SleepVasc w…
Precision management of autoimmune ocular complications: Th17 mechanisms and therapeutic innovations.
Precision management of ocular complications in systemic autoimmune diseases, such as Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), Behçet's disease, and thyroid-associated ophthalmopathy (TAO), requires integration of immune mechanisms with clinical translation. These disorders manif…
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is now recognized as a complex immune-mediated inflammatory disorder rather than a purely pauci-immune small-vessel vasculitis. Advances in understanding ANCA specificity, complement activation, neutrophil extracellular trap for…
Long-term rheumatologic comorbidities in familial Mediterranean fever.
Familial Mediterranean fever (FMF) is characterized by pyrin inflammasome dysregulation and chronic subclinical inflammation. Whether FMF carries an increased long-term burden of rheumatologic and autoimmune inflammatory disease is unclear. We evaluated baseline and long-term occurrence of rheumatol…
Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort.
Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, and throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common. The aim of this study was…
Systemic associations of pyoderma gangrenosum: a systematic review.
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that may be associated with systemic diseases. Characterizing these associations is clinically relevant for diagnosis, prognosis and management. To systematically review acquired systemic diseases associated with PG in adults and describe r…
Psychological Aspects of Rheumatic Diseases: Psychorheumatology in Clinical Practice.
Rheumatic diseases (RDs) significantly impact patients' physical, psychological, and social well-being, yet psychological dimensions remain inadequately addressed in routine clinical practice. In this commentary, we examine psychological manifestations and mental health comorbidities in RDs, such as…
Cocaine-induced ANCA-associated vasculitis: Cohort analysis from a referral center and literature review.
Cocaine adulterated with levamisole has been implicated as a trigger of Cocaine-Levamisole-Associated Autoimmune Syndrome (CLAAS), frequently mimicking granulomatosis with polyangiitis (GPA). To characterize the clinical, serologic, and histopathologic features of CLAAS and compare them with GPA. Re…