PCOS

125 papers & discussions

Polycystic Ovary Syndrome is a hormonal disorder causing irregular periods, excess androgens, and polycystic ovaries.

✦ AI summary

Here's what these sources cover on PCOS: PCOS isn't one uniform condition — researchers describe different "phenotypes" (combinations of irregular ovulation, high androgen hormones, and polycystic ovary appearance on ultrasound), and these phenotypes seem to carry different risks for pregnancy complications like preeclampsia, gestational diabetes, and miscarriage, whether conception happens naturally or through fertility treatment [3]. There's also discussion of renaming PCOS to better reflect its broader metabolic and hormonal nature, which could open up new directions for research, care, and advocacy [5]. On the biology side, studies in animal and cell models point to processes like impaired ovarian cell survival, mitochondrial problems, and lipid/fat metabolism disruptions as contributors to PCOS, with various compounds (vitamin D, a plant compound called scutellarin, gallic acid, short-chain fatty acids, and a protein called OGN) showing some ability to ease these problems in lab and animal studies [6,7,8,9,10]. Genetic research has also identified specific gene variations (in ERBB4 and SHBG) associated with higher PCOS risk in a South Indian population [4]

This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.

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Research

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PubMed

Safety monitoring of bivalent, quadrivalent, and 9-valent human papillomavirus vaccination in Japan: The vaccine effectiveness, networking, and universal safety (VENUS) study.

Safety data on human papillomavirus (HPV) vaccination in the Japanese population remain limited owing to the lack of healthcare databases available for vaccine safety assessment. In this study, we assessed the risk of adverse events of special interest (AESIs) following HPV vaccination among females…

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PubMed

Restoring ovulation in functional hypothalamic amenorrhea: impact of polycystic ovarian morphology on hormonal response to pulsatile GnRH.

Up to 50% of women with functional hypothalamic amenorrhea (FHA) exhibit polycystic ovarian morphology (PCOM) on ultrasound. We aimed to compare the hormonal response to ovulation induction with pulsatile GnRH therapy in FHA patients with and without PCOM. In this single-center observational study,…

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PubMed

Variation in gestational outcomes among PCOS phenotypes in natural and art-conceived pregnancies.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. While diagnostic criteria have historically varied, the Rotterdam criteria, established in 2003, are now the standard. This classification identifies four PCOS phenotypes based on the presence…

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PubMed

Association of ERBB4 and SHBG gene polymorphisms with polycystic ovarian syndrome in South Indian women: a case-control genetic analysis.

Polycystic ovary syndrome (PCOS) is a multifactorial endocrinological disorder with a substantial genetic component. However, the role of genes involved in follicular development and androgen regulation remains incompletely understood, particularly in South Indian populations. This study aimed to ev…

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PubMed

Beyond a Name Change: Polyendocrine Metabolic Ovarian Syndrome and a New Era of Opportunity for Research, Care, and Advocacy.

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PubMed

Vitamin D regulates lipid metabolism in granulosa cells via the FABP3-associated PI3K/Akt pathway in polycystic ovary syndrome.

To investigate whether vitamin D (VD) affects lipid metabolism in granulosa cells in polycystic ovary syndrome (PCOS) through the FABP3-associated PI3K/Akt pathway. PCOS rat models were established using letrozole, followed by ovarian transcriptome sequencing, which revealed significant enrichment o…

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PubMed

Short-Chain Fatty Acids Ameliorates Lipid Profile, Oxidative Stress and Inflammation in Letrozole Induced Polycystic Ovary Syndrome Rat Model.

Polycystic ovary syndrome (PCOS) is one of the most common metabolic-reproductive disorders affecting reproductive-age women, causing an irregular menstrual cycle, hyperandrogenism, and polycystic ovarian morphology. Current therapies for PCOS focus on the management of symptoms. Short-chain fatty a…

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PubMed

Scutellarin ameliorates PCOS mouse model by restoring mitochondrial function and inhibiting granulosa cell apoptosis.

Polycystic ovary syndrome (PCOS), a common endocrine-metabolic disorder, lacks effective therapeutic options. Granulosa cell (GC) apoptosis and mitochondrial dysfunction are critical drivers of ovarian dysfunction in PCOS, yet targeted therapies are scarce. Scutellarin, a bioactive flavonoid, is a p…

pcosmitochondrial disease
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