A 3.6:1 myo-inositol to D-chiro-inositol ratio and antioxidant-based food supplement before IVF improves fertility in women with PCOS: a pilot observational retrospective cohort study.
PCOS is frequently associated with metabolic disturbances, including a high prevalence of insulin resistance and compensatory hyperinsulinemia, which can impair reproductive outcomes. Previous evidence indicates that combining myo-inositol and D-chiro-inositol in a specific 3.6:1 ratio may support o…
Association of ERBB4 and SHBG gene polymorphisms with polycystic ovarian syndrome in South Indian women: a case-control genetic analysis.
Polycystic ovary syndrome (PCOS) is a multifactorial endocrinological disorder with a substantial genetic component. However, the role of genes involved in follicular development and androgen regulation remains incompletely understood, particularly in South Indian populations. This study aimed to ev…
Hotspots and research trends of exercise in polycystic ovary syndrome: a bibliometric analysis from 2005 to 2025.
Polycystic Ovary Syndrome (PCOS) imposes substantial metabolic and reproductive burdens. Exercise has emerged as a crucial lifestyle intervention, and corresponding scientific interest has expanded. This study provides a comprehensive bibliometric analysis of global research on the intersecting PCOS…
OGN inhibits apoptosis and ferroptosis via FSHR in human granulosa cells: implications for polycystic ovary syndrome.
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by granulosa cell dysfunction, including impaired proliferation, excessive apoptosis, and ferroptosis, which contribute to abnormal follicular development and ovarian dysfunction. This study aims to investigate…
Melatonin alleviates mitochondrial damage by regulating SIRT3‑mediated mitochondrial dynamics in granulosa cells under PCOS‑like conditions.
The present study investigated the role of melatonin (MT) in regulating mitochondrial function via sirtuin 3 (SIRT3) in granulosa cells (GCs) from patients with polycystic ovary syndrome (PCOS), with a focus on mitochondrial protection. Notably, GCs isolated from patients with PCOS exhibited mitocho…
Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance.
Extreme flooding driven by climate change demands strategies to enhance plant tolerance to low-oxygen stress. We investigated the ability of bioactive compounds to chemically prime plants for flooding events. A high-throughput chemical genetic screen of 2237 bioactive molecules was performed using a…
Testosterone Reference Ranges in Women, Adolescent Girls, and Children: The 2024 PCOS Challenge-CDC Stakeholder Meeting.
Testosterone measurement is fundamental to the management of many disorders in women, adolescent girls, and children, most notably androgen excess, including polycystic ovary syndrome (PCOS, aka Polyendocrine Metabolic Ovarian Syndrome [PMOS]) and congenital adrenal hyperplasia, and androgen deficie…