Addison's disease is adrenal insufficiency — the adrenal glands don't produce enough cortisol or aldosterone.
✦ AI summary
Addison's disease (primary adrenal insufficiency) is described in these sources as a rare condition that is often diagnosed late because symptoms can be vague, slow to develop, and easy to miss [3]. When comparing people with autoimmune-caused Addison's disease to those whose adrenal glands were surgically removed for other reasons, research finds similar overall quality of life between the two groups, but people with autoimmune adrenal insufficiency report more frequent adrenal crises (about 25% vs. 13% in the past year), even after accounting for glucocorticoid dosing [4]. This suggests the cause of adrenal insufficiency may affect crisis risk in ways not fully explained by hormone replacement management, pointing to a need for more tailored crisis-prevention strategies [4]. A related study on bilateral adrenal removal (a related but distinct route to permanent adrenal insufficiency) similarly found that adrenal crises occurred more often in people whose adrenal insufficiency came from Cushing's syndrome than from other causes, and that lifelong monitoring and hormone replacement are needed afterward [12]. Other sources touch on adrenal insufficiency in different contexts (e.g., cancer treatments, sep
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
Metastatic large cell neuroendocrine carcinoma: a rare cause of hypopituitarism.
Pituitary metastases from pulmonary large cell neuroendocrine carcinoma (LCNEC) are exceedingly rare but should be considered in patients presenting with arginine vasopressin deficiency and panhypopituitarism in the context of known or suspected metastatic lung cancer. Early recognition and prompt i…
Challenges in managing endocrine and metabolic dysfunction in a child with Prader-Willi syndrome and medulloblastoma.
Prader-Willi syndrome (PWS) is a complex genetic disorder characterized by severe hyperphagia, early-onset obesity, developmental delay, behavioral disturbances, and multiple endocrine dysfunctions. Clinical management is especially challenging when complicated by central nervous system tumors, whic…
[Hydrocortisone for septic shock: with or without fludrocortisone?].
The authors of both national and international sepsis guidelines leave it up to clinician discretion whether hydrocortisone should be supplemented with fludrocortisone in cases of septic shock. The aim of this review is to present and discuss the available evidence and the rationale behind the combi…
Adrenal crises and quality of life after bilateral adrenalectomy vs primary autoimmune adrenal insufficiency.
Bilateral adrenalectomy (BLA) and autoimmune adrenal insufficiency (AAI) are 2 major causes of primary adrenal insufficiency (PAI). Comparative data between etiologies are limited. To compare management, quality of life (QoL), and frequency of adrenal crises between participants post-BLA vs AAI. We…
Protracted osilodrostat-induced pan-adrenal steroidogenic suppression and adrenal size reduction in Cushing disease.
Osilodrostat, a potent 11β-hydroxylase inhibitor, is used for Cushing syndrome. Transient adrenal insufficiency during dose titration is common and usually reversible, whereas prolonged adrenal insufficiency after treatment discontinuation appears uncommon. A man with treatment-resistant Cushing dis…
Toxicity profile and tolerability of immune checkpoint inhibitors for the treatment of early-stage breast cancer: a systematic review and meta-analysis.
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have demonstrated clinical benefit in early-stage breast cancer (eBC), enhancing antitumor immune responses. However, their incorporation into perioperative polychemotherapy has introduced new concerns regarding safety and immune-rela…
The Hidden Burden: Endocrinopathies in Adolescents after Hematopoietic Stem Cell Transplantation.
Adolescents with malignant and nonmalignant diagnoses can require hematopoietic stem cell transplantation (HSCT), with the volume increasing 5% to 10% per annum in the United States. HSCT is an established therapy for malignancies, hemoglobinopathies, bone marrow failure, inborn errors of metabolism…
Delay in Diagnosis of Addison's Disease: A Case Report and Literature Review.
Primary adrenal insufficiency is a rare disorder prone to delay in diagnosis after initial presentation. Multiple factors including a wide range of presentations, slow onset of symptoms, and other human factors may be contributing to challenges with the diagnosis.