A rare disease causing recurrent inflammation of cartilage, affecting the ears, nose, and airways.
✦ AI summary
The sources here give only limited, indirect information about Relapsing Polychondritis. One source describes a case where relapsing polychondritis occurred together with alkaptonuria (a metabolic disorder) and psoriatic arthritis, showing symptoms like ear thickening and tenderness, eye inflammation, elevated inflammation markers, and cartilage biopsy findings of lymphocytic infiltration [7]. Beyond this single case report, none of the other provided sources discuss relapsing polychondritis directly — they cover unrelated topics like fatigue syndrome, kidney disease, Raynaud's phenomenon, rheumatoid arthritis, lupus, and IBD [1–6, 8–12]. So, based on these sources, there isn't enough information to give a broader picture of typical symptoms, causes, or treatment approaches for relapsing polychondritis beyond this one case example.
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
This study explored whether Lycium ruthenicum polysaccharide (LRP) influences gut microbiota-derived short-chain fatty acids (SCFAs) and neuroinflammatory responses in a sleep deprivation-induced CFS-like mouse model. Oral LRP was associated with improved fatigue-related behavioral performance, redu…
me cfslupuschronic fatiguerelapsing polychondritis
Identifying candidate core domains for clinical trials in systemic sclerosis-associated Raynaud's phenomenon and digital ulcers.
The OMERACT Scleroderma Vascular Disease Working Group sought to identify essential core outcome domains for inclusion in clinical trials focusing on Raynaud's phenomenon (RP) and/or digital ulcers (DUs) related to systemic sclerosis (SSc). Candidate domains identified from previous qualitative work…
A Rare Association of Anti-SRP Antibody-Positive Immune-Mediated Necrotizing Myopathy and Sjögren Disease: Two Case Reports.
Immune-mediated necrotizing myopathy (IMNM) is an autoimmune myositis which is characterized by severe muscle fiber necrosis and refractoriness to immunotherapies. Overlap between myositis and other autoimmune disorders is well-recognized; however, the coexistence of IMNM and Sjögren disease (SjD) i…
Circulating Antinephrin Antibodies in Adult Chinese Patients With IgAN and Nephrotic-Range Proteinuria.
Antinephrin autoantibodies are detectable in podocytopathies such as minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS); however, their prevalence and clinical relevance in IgA nephropathy (IgAN) with nephrotic-range proteinuria (NRP) and nephrotic syndrome (NS) are u…
Raynaud's phenomenon: a vascular or an autoimmune-mediated disorder? Facts and fancy.
Raynaud's phenomenon (RP) is a common vasospastic disorder characterized by transient digital ischemia triggered by cold exposure or emotional stress. It is classified as primary or secondary, the latter often associated with autoimmune connective tissue diseases such as systemic sclerosis, mixed co…
Folding the message: mRNA structure as a regulatory layer of human mitochondrial gene expression.
Mammalian mitochondrial gene expression operates within an unusually compact genomic architecture in which most regulatory information must be encoded within or immediately adjacent to protein-coding sequences. In this context, mitochondrial mRNAs function not merely as templates for translation but…
Polychondritis and Arthritis in a Patient with Coexisting Alkaptonuria and Psoriasis Vulgaris.
Alkaptonuria is an organic acid metabolic disorder caused by abnormalities of the tyrosine metabolic pathway. Herein, we report a case of relapsing polychondritis and arthritis in a patient with alkaptonuria and psoriasis vulgaris, respectively. A 53-year-old man, previously diagnosed with alkaptonu…
Evaluating clinical heterogeneity in relapsing polychondritis through unsupervised cluster analysis.
As a rare autoimmune disease, relapsing polychondritis (RP) exhibits individual variations in clinical manifestations, treatment response and prognosis. To date, no biomarkers have been implemented to clinical practice.This study aimed to apply cluster analysis to identify the clinical phenotype, cl…