A rare disease causing recurrent inflammation of cartilage, affecting the ears, nose, and airways.
✦ AI summary
Research on relapsing polychondritis (a rare autoimmune condition causing inflammation of cartilage, which can seriously affect breathing) covers a few specific angles. One study looked at a type of imaging scan (18F-FDG PET/CT) and found it was often "positive" in people with this condition, even picking up cartilage inflammation in over a quarter of patients who had no symptoms in that area — it was especially useful for spotting problems in hard-to-reach airway areas and for tracking treatment response, though the researchers say larger studies are still needed [1]. A case report describes a man whose relapsing polychondritis caused airway narrowing detected on CT and bronchoscopy, and whose symptoms and airway problems improved with high-dose steroids and a chemotherapy-type immune-suppressing drug (cyclophosphamide), which the authors say underscores the value of catching the disease early and monitoring the airway over time [4]. Separately, a broader review of two related immune-modulating drugs (abatacept and belatacept) mentions that lower-quality evidence has reported positive results using abatacept for relapsing polychondritis, among other autoimmune conditions [5]. Overall, the available sources are limited in scope — they touch
This is an AI-generated summary of the sources below — not medical advice. Always talk to a doctor or pharmacist about your own situation.
The utility of 18F-fluorodeoxyglucose PET/computed tomography in relapsing polychondritis: a systematic review and meta-analysis.
Relapsing polychondritis is a rare chronic autoimmune inflammation of the cartilage associated with life-threatening respiratory complications. Currently, no clear role of imaging modalities such as 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) is defined in the literature. This systemat…
Microvascular barrier - Transdermal and Topical drug delivery in Raynaud's Phenomenon.
Raynaud Phenomenon (RP) is a peripheral vascular disease that results in episodes of vasospasm of the microcirculation of hands and feet, which causes ischemia, pain and functional deficiency. Traditional systemic treatments of RP, such as calcium channel blockers and phosphodiesterase type-5 inhibi…
A systematic review of abatacept and belatacept in immune-mediated diseases.
Abatacept (ABA) and belatacept (BEL) are immunomodulatory fusion proteins in which the extracellular domain of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is linked to the Fc fragment of human IgG1. Functionally, they bind to cell surface antigens CD80 and CD86 on antigen-presenting cells,…
Relapsing Polychondritis Presenting With Diffuse Tracheal Inflammation.
A 59-year-old man presented with sore throat and cough, and chest computed tomography and bronchoscopy revealed airway stenosis. Four McAdam's criteria supported the diagnosis of relapsing polychondritis. High-dose prednisolone and cyclophosphamide improved symptoms and airway lesions, highlighting…
WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
This study explored whether Lycium ruthenicum polysaccharide (LRP) influences gut microbiota-derived short-chain fatty acids (SCFAs) and neuroinflammatory responses in a sleep deprivation-induced CFS-like mouse model. Oral LRP was associated with improved fatigue-related behavioral performance, redu…
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Identifying candidate core domains for clinical trials in systemic sclerosis-associated Raynaud's phenomenon and digital ulcers.
The OMERACT Scleroderma Vascular Disease Working Group sought to identify essential core outcome domains for inclusion in clinical trials focusing on Raynaud's phenomenon (RP) and/or digital ulcers (DUs) related to systemic sclerosis (SSc). Candidate domains identified from previous qualitative work…
Polychondritis and Arthritis in a Patient with Coexisting Alkaptonuria and Psoriasis Vulgaris.
Alkaptonuria is an organic acid metabolic disorder caused by abnormalities of the tyrosine metabolic pathway. Herein, we report a case of relapsing polychondritis and arthritis in a patient with alkaptonuria and psoriasis vulgaris, respectively. A 53-year-old man, previously diagnosed with alkaptonu…
Circulating Antinephrin Antibodies in Adult Chinese Patients With IgAN and Nephrotic-Range Proteinuria.
Antinephrin autoantibodies are detectable in podocytopathies such as minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS); however, their prevalence and clinical relevance in IgA nephropathy (IgAN) with nephrotic-range proteinuria (NRP) and nephrotic syndrome (NS) are u…