PubMed
Ozone therapy by rectal insufflation in long COVID syndrome: a preliminary study with thermographic evaluation and quality of life measurement.
long covid
Persistent symptoms lasting weeks or months after a COVID-19 infection, affecting multiple organ systems.
✦ AI summary
Long COVID (also called post-acute COVID-19 syndrome) involves lasting symptoms like fatigue, brain fog, pain, shortness of breath, and dizziness that can persist for months and impair daily functioning [1][5][12]. Research shows it's linked to real physical changes: many patients show signs of "central sensitization" (an overactive nervous system response to symptoms), reduced blood flow to the brain on standing, and markers of inflammation [4], while some studies of children describe autonomic nervous system problems affecting heart rate and blood pressure regulation [12]. One population-based study found only modest overall organ differences between people with Long COVID and others, except for higher blood pressure, suggesting some symptoms may not come from detectable organ damage [9]. Long COVID also carries a practical burden — it's associated with higher healthcare costs [2] and lower odds of staying employed or maintaining normal work hours [3], and persistent symptoms after infections in general (not just COVID) are common and cause notable daily impairment [5]. As for treatments, a small preliminary study suggested ozone therapy might improve strength and quality of life, but the study was uncontrolled and small [1]; a review of immune-modulating treatments (
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