Comprehensive evaluation of tick infestation dynamics and host response in Kankrej and Holstein Friesian crossbred cattle.
Ticks and tick-borne diseases present significant challenges to cattle production. In this context, natural host resistance to ticks emerges as a promising and sustainable alternative. The present study aimed to clarify the phenotypic, immunological, and genetic factors contributing to the superior…
Postmortem tryptase as a diagnostic marker in fatal anaphylaxis: A systematic review and meta-analysis.
Fatal anaphylaxis remains a diagnostically challenging condition in forensic practice, particularly in the postmortem setting where clinical information is often limited. Postmortem serum tryptase has been widely proposed as a marker of mast cell activation, but its quantitative significance and dia…
A Real-World Cross-Sectional Study on Suspected Mast Cell Activation Syndrome: Multiple Heterogeneous Symptoms Identified.
A variety of clinical signs and symptoms have been described in patients suspected of having mast cell activation syndrome (MCAS), however, symptom patterns and linked organ systems were not yet described. This cross-sectional online survey included adults with physician-diagnosed self-assessed or s…
Coexistence of Multiple Myeloma, Mast Cell Hyperplasia, and Low-Level Myeloid Blastocytosis: A Report of a Rare Case.
BACKGROUND Mast cell hyperplasia can present as systemic mastocytosis (SM) or reactive mast cell hyperplasia. Distinguishing between these 2 diseases is a critical challenge. Here, we report a rare case of concurrent mast cell hyperplasia, multiple myeloma (MM), and low-level myeloid blastocytosis.…
Melastoma dodecandrum polysaccharide alleviates urticaria via the gut-skin axis by modulating the gut microbiota and the NGF/TRPV1/p38 MAPK pathway.
Urticaria is a recurrent inflammatory skin disorder characterized by mast cell activation, neuroimmune dysregulation, and gut microbiota imbalance. Current therapies are associated with limited efficacy and high relapse rates. Although Melastoma dodecandrum Lour. has traditionally been used to treat…
Oral Chinese patent medicine alleviates atopic dermatitis by regulating ALOX15-derived oxylipins disorder.
Atopic dermatitis (AD) is a chronic inflammatory skin disease often exacerbated by psychological stress, yet the underlying mechanisms remain unclear. Wushe Zhiyang Pills (WZP), an oral Chinese patent medicine, is clinically used for dermatological conditions, but its efficacy and mechanisms in stre…