Integrating basal and reserve salivary function defines clinically anchored functional phenotypes and contextualises salivary end points in Sjögren's disease.
Salivary gland dysfunction in Sjögren's disease (SjD) is clinically heterogeneous. Unstimulated whole salivary flow (UWSF) reflects basal secretion, while stimulated tests such as the Saxon test assess secretory reserve. Whether integrating these complementary domains defines clinically meaningful g…
Comparative Value of Traditional versus Novel Immune-Inflammatory Indices in Assessing Disease Activity of Sjögren's Disease: A Multicenter Cohort Study.
To evaluate the comparative value of traditional clinical features and novel immune-inflammatory indices in assessing disease activity in primary Sjögren's Disease (SjD), and to construct a robust classification model for moderate-to-severe disease activity using a machine learning approach. This cr…
Vascular Endothelial Barrier in Salivary Glands: From Physiological Regulation to Pathological Impairment of Secretion.
Although salivary glands are highly vascularized, the microvascular endothelial barrier has only recently emerged as a pivotal determinant of glandular homeostasis and disease. This review synthesizes current understanding of the salivary gland endothelial barrier, with particular emphasis on the re…
Which features best differentiate Sjögren's-related from non-Sjögren's-related dry eye disease?
To identify which features best differentiate Sjögren's-related from non-Sjögren's related dry eye disease (DED) using machine-learning models. A retrospective study was conducted on 324 individuals with DED based on Dry Eye Workshop-II criteria, including 162 with and 162 without Sjögren's disease…
Sjögren's disease (SjD) is a chronic progressive autoimmune disorder primarily affecting the exocrine glands. Dacryoadenitis represents one of the typical clinical manifestations of SjD, yet its underlying pathogenic mechanisms remain poorly understood. This study investigated the immune microenviro…
Functional insights into autoantibodies targeting muscarinic acetylcholine receptors in Sjögren's disease.
G protein-coupled receptors (GPCRs) participate in various pathophysiological processes in Sjögren's disease (SjD); in particular, autoantibodies against muscarinic acetylcholine receptor 3 (M3R) inhibit the secretion of saliva and tears by exocrine glands. We aimed to identify autoantibodies target…
Primary Sjogren syndrome with suspected central nervous system inflammatory involvement.
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder primarily affecting exocrine glands but frequently associated with extra glandular manifestations, including neurological involvement. Central nervous system (CNS) involvement is a rare and potentially severe manifestation of pSS, oft…