An inflammatory arthritis primarily affecting the spine, causing pain and progressive spinal fusion.
✦ AI summary
Research on ankylosing spondylitis (AS) covers diagnosis, imaging, treatment, and possible disease mechanisms, though diagnosis remains tricky because there's no single definitive test, often causing delays in getting diagnosed [5]. Imaging research is active: newer "synthetic CT" scans derived from MRI can detect spinal damage (like joint fusion, erosions, and bony growths) about as accurately as regular CT, which could reduce radiation exposure [2], while advanced PET scans can help distinguish AS-related bone changes from ordinary wear-and-tear changes during treatment [8]. On treatment, a review of therapy options notes that anti-inflammatory drugs (NSAIDs) are typically first-line and may be linked to slower spinal damage progression in some patients, TNF-inhibitor biologics have the strongest evidence for slowing structural spine damage, IL-17 inhibitors help symptoms well with low damage progression (though it's unclear if they directly cause that effect), and newer JAK inhibitor drugs control symptoms but haven't yet proven they stop structural damage; regular exercise (especially shorter sessions) and maintaining healthy weight were also linked to better out
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