Recognition of Cutaneous Symptoms of Common Tick-Borne Illness in the Emergency Department.
Tick-borne diseases occur throughout the United States, with a disease burden that ranges from mild to severe. As temperatures rise with climate change, the active season for ticks increases, and more tick-borne illness is seen (Centers for Disease Control and Prevention, 2022a). Many patients prese…
Tick-borne pathogens in dogs and their ticks in France: Molecular and serological evidence from a multicenter participatory study.
Canine tick-borne diseases (TBDs) are expanding globally, representing an increasing concern for both veterinary and public health. Dogs, due to their close contact with humans and frequent exposure to ticks, may serve as valuable sentinels for zoonotic risk. Between December 2022 and December 2023,…
Molecular detection of Borrelia burgdorferi sensu lato in questing ticks: One year of sampling in Bologna (Northern Italy).
Borrelia burgdorferi sensu lato (s.l.) includes several genospecies responsible for Lyme borreliosis (LB), a major zoonotic disease transmitted by Ixodes spp. ticks. In Western Europe, LB incidence has risen in recent decades, with documented expansion into previously non-endemic regions. A cross-se…
Cardiovascular Autonomic Dysfunction in Late-Stage Lyme Disease: A Comprehensive Autonomic Assessment.
Lyme disease, caused by Borrelia burgdorferi sensu lato, may lead to persistent complications, including autonomic nervous system dysfunction. Although postural orthostatic tachycardia syndrome is frequently associated with orthostatic intolerance in Lyme disease, broader autonomic impairment remain…
Photopolymerizable placenta-derived ECM hydrogel enhances hUC-MSC-mediated wound healing via coordinated immunomodulation and angiogenesis.
Mesenchymal stromal/stem cells (MSCs) hold great promise for regenerative medicine due to their potent immunomodulatory properties and favorable safety profile. However, their low survival, poor retention, and limited engraftment in injured tissues remain major barriers to clinical efficacy. Here, w…
Therapeutic plasma exchange and immunomodulatory strategies in post-infectious syndromes: A review of immune dysregulation in PTLDS, long COVID, ME/CFS, and PANS/PANDAS.
Post-infectious syndromes including post-treatment Lyme disease syndrome (PTLDS), long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and pediatric acute-onset neuropsychiatric syndrome (PANS)/pediatric autoimmune neuropsychiatric disorders associated with streptococcal infectio…
Stimulating Thyrotropin Receptor Antibodies Enhance the Expression of Both Thyrotropin Receptors and Insulin-Like Growth Factor 1 Receptors in Fibroblasts.
Thyrotropin (TSH) and insulin-like growth factor 1 (IGF-1) signals have been shown to be additive in their action on thyroid cells and fibroblasts, and this coordination emphasizes the role of TSH receptor (TSHR) and IGF-1 receptor (IGF-1R) signaling exerted by stimulating TSHR antibodies in patient…
Neuroborreliosis in children: Focus on ischemic stroke-a case report and literature review.
Lyme borreliosis-the most prevalent tick-borne disease in the United States, Canada and Europe-is a systemic infection caused by the spirochete Borrelia burgdorferi that can spread to the nervous system, where it may manifest as neuroborreliosis with potentially severe complications. Despite a world…